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Adipocyte-specific Adhesion Molecule(ACAM/ASAM)

Alternative name:

  • adipocyte-specific adhesion molecule
  • Coxsackie- and adenovirus receptor-like membrane protein

Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia

OBJECTIVES: The aim of this study was to investigate the modulatory effect of the coxsackie and adenovirus receptor (CAR) on ventricular conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
BACKGROUND: A heritable component in the risk of ventricular fibrillation during myocardial infarction has been well established. A recent genome-wide association study of ventricular fibrillation during acute myocardial infarction led to the identification of a locus on chromosome 21q21 (rs2824292) in the vicinity of the CXADR gene. CXADR encodes the CAR, a cell adhesion molecule predominantly located at the intercalated disks of the cardiomyocyte.
METHODS: The correlation between CAR transcript levels and rs2824292 genotype was investigated in human left ventricular samples. Electrophysiological studies and molecular analyses were performed using CAR haploinsufficient (CAR⁺/⁻) mice.
RESULTS: In human left ventricular samples, the risk allele at the chr21q21 genome-wide association study locus was associated with lower CXADR messenger ribonucleic acid levels, suggesting that decreased cardiac levels of CAR predispose to ischemia-induced ventricular fibrillation. Hearts from CAR⁺/⁻ mice displayed slowing of ventricular conduction in addition to an earlier onset of ventricular arrhythmias during the early phase of acute myocardial ischemia after ligation of the left anterior descending artery. Expression and distribution of connexin 43 were unaffected, but CAR⁺/⁻ hearts displayed increased arrhythmia susceptibility on pharmacological electrical uncoupling. Patch-clamp analysis of isolated CAR⁺/⁻ myocytes showed reduced sodium current magnitude specifically at the intercalated disk. Moreover, CAR coprecipitated with NaV1.5 in vitro, suggesting that CAR affects sodium channel function through a physical interaction with NaV1.5.
CONCLUSIONS:CAR is a novel modifier of ventricular conduction and arrhythmia vulnerability in the setting of myocardial ischemia. Genetic determinants of arrhythmia susceptibility (such as CAR) may constitute future targets for risk stratification of potentially lethal ventricular arrhythmias in patients with coronary artery disease.
Marsman RF et al. J Am Coll Cardiol. 2014 Feb 18;63(6):549-59
 
  Anti Human Adipocyte-Specific Adhesion Molecule (ASAM) IgG
Code No.: A00369-01-100
Size: 100 ug
Price: $260.00 USD
Host: Rabbit
Antigen: ECD of human ASAM/ACAM Rec.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC
Working Dilution: IHC 1: 200 (5 ug/ml)
Data Sheet: PDF

human ASAM recombinant

Human Adipocyte-specific Adhesion Molecule (ASAM/ACAM), Extracellular Domain Recombinant
Code No.: 00369-01-100
Size: 100 ug
Price: $360.00 USD
Protein ID:Q9H6B4
Gene ID: 79827
MW: 27 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 90%
Data Sheet: PDF

 

Name
Code No.
Size
Price ($)
Human ACAM/ASAM , ECD, recombinant
100 ug
360.00
Anti Human ACAM/ASAM Rabbit IgG
100 ug
260.00
ACAM/ASAM, (Human) Rec. (293 cells derived)
00369-06-10
10 ug
100.00
Anti ACAM (Human) Rabbit IgG
A00369-06-100
100 ug
290.00
ACAM, Rec. (Mouse) (293 cells derived)
00369-03-10
10 ug
100.00
Anti ACAM (Mouse) Rabbit IgG
A00369-03-100
100 ug
290.00
ACAM, Rec. (Rat) (293 cells derived)
00369-02-10
10 ug
100.00