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Bone Morphogenetic Protein 7 (BMP7)ELISA Kit
 
 
BMP7 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as preproBMPs, cleaved, and then processed into dimeric proteins. BMP7 induces bone and cartilage formation.
 

Circulating bone morphogenetic protein-7 and transforming growth factor-β1 are better predictors of renal end points in patients with type 2 diabetes mellitus

Albuminuria and a reduced glomerular filtration rate are conventional predictors of a future decline in kidney function in patients with type 2 diabetes mellitus. Using a nested case-control study we assessed whether circulating transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) levels more accurately predict renal end points than the conventional markers. Cases were defined as those who developed a renal end point (doubling of serum creatinine to at least 200 μmol/l, the need for renal replacement therapy, or death due to renal disease) during the study. Using propensity scoring, two controls were selected for each of 281 cases. Participants who developed renal end points had significantly higher total TGF-β1, lower BMP-7 levels, and a higher total TGF-β1 to BMP-7 ratio at baseline. A graded increase in risk was found in individuals with lowerBMP-7 levels (odds ratio 24.07, for the lowest to the highest tertile), or significantly higher TGF-β1 levels (odds ratio for the highest to the lowest tertile, 8.43). The area under the receiver operating characteristic curve (c-statistic) for the conventional predictors was 0.73. Using BMP-7 and total and active TGF-β1, the c-statistic was 0.94 (significantly higher to conventional predictors). Thus, our results suggest these novel kidney markers are better predictors of renal progression than the conventional predictors in patients with type 2 diabetes mellitus.
Wong MG et al. Kidney Int. 2013 Feb;83(2):278-84. doi: 10.1038/ki.2012.383. Epub 2012 Dec 12.
human BMP7 elisa kit from aviscera bioscience
Human BMP7 ELISA Kit
Code No.: SK00019-01
Size: 96 T
Price: $360.00 USD
Standard range: 15.6-1000 pg/ml
Sensitivity: 5 pg/ml
Sample type: serum, plasma, cell cultures
Sample require: 100uL per well
Intra-CV: 4-6%
Inter-CV:8-10%
Protocol: PDF
   
human BMP7 recombinant
Human BMP7 (Mature form)
Code No.: 00019-02-100
Size: 100 ug
Price: $360.00 USD 
Protein ID:P18075
Gene ID: 655
MW: 18.6 KD
Tag: His Tag on N-Terminus 
Expressed: E. Coli 
Purity: 95% 
Data Sheet: PDF

 

Anti Human Pro-BMP7 IgG
Code No.: A00019-02-100
Size: 100 ug
Price: $220.00 USD
Host: Rabbit
Antigen: human BMP7 Rec.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E
Working Dilution: 1000
Data Sheet: PDF

 

Name
Code No.
Size
Price ($)
BMP-7 (Human) ELISA Kit SK00019-01 96 T  360.00
BMP-7 Mature form (Human) Rec.
10 ug
60.00
BMP-7 Mature form (Human) Rec.
100 ug
360.00
Rabbit Anti Pro-BMP7 (H) IgG
A00019-02-100
100 ug
220.00