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Soluble CD38(human) ELISA
Biomarker for cancer, diabetes and osteoporosis research
The CD38 was expressed expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 synthesized cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. CD38 indicated cADPr hydrolase activity. CD38 belongs to single-pass type II membrane protein. CD38 functions in cell adhesion, signal transduction and calcium signaling. Defects of CD38 is associated with impaired immune responses, metabolic disturbances, and behavioral modifications, and thus has been connected to HIV infection, leukemias, myelomas, solid tumors, type I I diabetes mellitus and bone metabolism.

 

human soluble CD38 from aviscera bioscience
human soluble CD38 elisa kit from aviscera bioscience

Multiple metamorphoses of CD38 from prognostic marker to disease modifier to therapeutic target in chronic lymphocytic leukemia

Human CD38, an ecto-enzyme and a receptor, performs as an independent negative prognostic marker for patients with chronic lymphocytic leukemia (CLL), a hematological malignancy characterized by the accumulation of a population of mature B lymphocytes expressing CD5. Patients with aCD38⁺ CLL clone display a more aggressive form of the disease with earlier treatment requirements and ultimately shorter overall survival than patients with a CD38⁻ clone. Several lines of evidence indicate that CD38 is not only a diagnostic marker but also a key element in the molecular network regulating disease maintenance and progression. First, CD38 is a receptor that induces proliferation and increases survival of CLL cells. Second, CD38 signals facilitate access of CLL cells to growth-favorable districts. This is achieved by enhancing i) chemotaxis towards CXCL12, ii) integrin-mediated adhesion and iii) matrix metalloprotease synthesis and secretion. Third, blocking monoclonal antibodies targeting CD38 impair CLL homing to spleen and bone marrow in xenograft models. These functions appear to be modulated by frontal interactions with CD31 as well as by lateral associations on the CLL membrane to form a large supramolecular complex similar to the invadosomes of epithelial cells. Our understanding has evolved from considering CD38 as a marker of unfavorable prognosis to recognizing its function as a disease modifier. Studies in the next few years will likely determine whether the molecule can also serve as a target for new therapies, using monoclonal antibodies, inhibitors of the enzymatic activity or both.
Vaisitti T et al. Curr Top Med Chem. 2013;13(23):2955-64.

CD38 and bone marrow microenvironment.

This review summarizes the events ruled by CD38 shaping the bone marrow environment, recapitulating old and new aspects derived from the body of knowledge on the molecule. The disease models considered were myeloma and chronic lymphocytic leukemia (CLL). CD38 has been analyzed considering its twin function as receptor and enzyme, roles usually not considered in clinics, where it is used as a routine marker. Another aspect pertaining basic science concerns the role of the molecule as a member of an ectoenzyme network, potentially metabolizing soluble factors not yet analyzed (e.g., NAD+, ATP, NAM) or influencing hormone secretion (e.g., oxytocin). The last point is focused on the use of CD38 as a target of an antibody-mediated therapeutic approach in myeloma and CLL. A recent observation is that CD38 may run an escape circuit leading to the production of adenosine. The generation of local anergy may be blocked by using anti-CD38 antibodies. Consequently, not only might CD38 be a prime target for mAb-mediated therapy, but its functional block may contribute to general improvement in cancer immunotherapy and outcomes.
Chillemi A et al. Front Biosci (Landmark Ed). 2014 Jan 1;19:152-62.
 
   
  Human Soluble CD38 ELISA Kit
Code No.: SK00497-01
Size: 96 T
Price: $420.00 USD
Standard range:39.1-2500 pg/ml
Sensitivity: 20 pg/ml
Sample Type: cell cultures
sample require:100 uL per well
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet: PDF

 

Human Soluble CD38 Recombinant
Code No.: 00497-01-10
Size: 10 ug
Price: $150.00 USD
Protein ID:NP_001766
Gene ID: NM_001775
MW:44 KD
Tag: His Tag on C-Terminus
Expressed: 293 cells derived
Purity: 97%
Data Sheet: PDF
Anti Human Soluble CD38 IgG
Code No.: A00497-01-50
Size: 50 ug
Price: $260.00 USD
Host: Rabbit
Antigen: human CD38 ECD
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, WB
Working Dilution: 1-2 ug/ml)
Data Sheet: PDF

 

 

Name
Code No.
Size
Price ($)
Soluble CD38 (Human) ELISA Kit SK00497-01 96 T 420.00
Soluble CD38(Human) standard
00497-01-10
10 ug
150.00
Anti Soluble CD320 (Human) Monoclonal Antibody
00497-01-50
50 ug
280.00
Anti Soluble CD320 (Human) IgG
A00497-01-100
100 ug
350.00