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CTRP13/C1QTNF13 ELISA, Recombinant & Antibodies
  • C1q/TNF-related protein 13
  • C1q-like 3

Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling

Members of the C1q/TNF family play important and diverse roles in the immune, endocrine, skeletal, vascular, and sensory systems. Here, we identify and characterize CTRP13, a new and extremely conserved member of the C1q/TNF family. CTRP13 is preferentially expressed by adipose tissue and the brain in mice and predominantly by adipose tissue in humans. Within mouse adipose tissue, CTRP13 is largely expressed by cells of the stromal vascular compartment. Due to sexually dimorphic expression patterns, female mice have higher transcript and circulating CTRP13 levels than males. CTRP13 transcript and circulating levels are elevated in obese male mice, suggesting a potential role in energy metabolism. The insulin-sensitizing drug rosiglitazone also increases the expression of CTRP13 in adipocytes, which correlates with the insulin-sensitizing action of CTRP13. In a heterologous expression system, CTRP13 is secreted as a disulfide-linked oligomeric protein. When co-expressed, CTRP13 forms heteromeric complexes with a closely related family member, CTRP10. This heteromeric association does not involve conserved N-terminal Cys residues. Functional studies using purified recombinant protein demonstrated that CTRP13 is an adipokine that promotes glucose uptake in adipocytes, myotubes, and hepatocytes via activation of the AMPK signaling pathway. CTRP13 also ameliorates lipid-induced insulin resistance in hepatocytes through suppression of the SAPK/JNK stress signaling that impairs the insulin signaling pathway. Further, CTRP13 reduces glucose output in hepatocytes by inhibiting the mRNA expression of gluconeogenic enzymes, glucose-6-phosphatase and the cytosolic form of phosphoenolpyruvate carboxykinase. These results provide the first functional characterization of CTRP13 and establish its importance in glucose homeostasis.
Wei Z, Peterson JM, Wong GW. J Biol Chem. 2011 May 6;286(18):15652-65. Epub 2011 Mar 4.
human CTRP13 elisa kit from aviscera bioscience Human CTRP13 ELISA KIt
Code No.: SK00333-06
Size: 96 T
Price: $460.00 USD 
Standard range: 7.8- 500 ng/ml
Sensitivity: 2 ng/ml
Sample Type: serum
Sample require: 100 uL per well
Intra-CV:4-6%
Inter-CV: 8-10% 
Protocol: PDF
human mouse CTRP3 recombinant from aviscera bioscience CTRP13 Full Length (Human, Mouse) Recombinant
Code No.: 00333-03-100
Size: 100 ug
Price: $360.00 USD
Protein ID:Q5VWW1
Gene ID:NM_001010908
MW:28.5 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 90%
Data Sheet: PDF
human mouse CTRP3 recombinant from aviscera bioscience
CTRP13 Globular Form (Human, Mouse) Recombinant
Code No.: 00333-03-100
Size: 100 ug
Price: $360.00 USD
Protein ID:B0LXL6
Gene ID:NM_153155
MW:18.6 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 90%
Data Sheet: PDF
anti ctrp 13 antibody for immunohistochemistry from aviscera biooscience
Anti CTRP13 (Human, Mouse) IgG
Code No.: A00333-07-100
Size: 100 ug
Price: $260.00 USD
Host: Rabbit
Antigen: human CTRP13
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC, WB
Working Dilution: IHC 2-4 ug/ml
Data Sheet: PDF
Name
Code No.
Size
Price ($)
CTRP13 (Human) ELISA Kit SK00333-06 96 T 460.00
CTRP13 (Human) ELISA Kit SK00333-06 192 T 897.00
CTRP13 (Human) ELISA Kit SK00333-06 480 T 2185.00
CTRP13 (Human) ELISA Kit SK00333-06 960 T 4140.00
CTRP3 Full Length (Human, Mouse) Rec. 00333-01-100 100 ug 390.00
CTRP13 Globular Form (Human,Mouse), Rec.
100 ug
360.00
Anti CTRP13 (Human, Mouse) IgG
100 ug
260.00
Anti CTRP13 (Human, Mouse) IgG Biotinylated
50 ug
300.00
Anti CTRP13 (Human, Mouse) IgG,FITC Conjugated
A00333-01-50F
50 ug
359.00
Anti CTRP13 (Human) Monoclonal Antibody
100 ug
290.00
Anti CTRP13 (Human) Monoclonal Antibody
100 ug
350.00
Anti CTRP13 (Human) Monoclonal Antibody
100 ug
290.00
Anti CTRP13 (Human) Monoclonal Antibody
100 ug
350.00
Anti CTRP13 (Human) Monoclonal Antibody
100 ug
290.00
Anti CTRP13 (Human, Mouse) IgG
100 ug
260.00
Anti CTRP13 (Human, Mouse) IgG, Biotinylated
50 ug
359.00
Anti CTRP13 (Human, Mouse) IgG, Cy3 Conjugated
A00333-07-50C3
50 ug
450.00