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Human Total Cathepsin S ELISA KIt |
A biomarker for cardiovascular
diseases and metabolic syndrome |
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Serum cathepsin S is associated with serum C-reactive protein and
interleukin-6 independently of obesity in elderly men
OBJECTIVE: Cathepsin S has been suggested provide a mechanistic link between
obesity and atherosclerosis, possibly mediated via adipose
tissue-derived inflammation. Previous data have shown an association
between circulating cathepsin S and inflammatory markers in the obese,
but to date, community-based reports are lacking. Accordingly, we
aimed to investigate the association between serum levels of cathepsin
S and markers of cytokine-mediated inflammation in a community-based
sample, with prespecified subgroup analyses in nonobese participants.
METHODS:
Serum cathepsin S, C-reactive protein (CRP), and IL-6 were measured
in a community-based cohort of elderly men (Uppsala Longitudinal Study
of Adult Men; mean age 71 years, n = 991). CRP and IL-6 were also
measured at a reexamination after 7 yr.
RESULTS:
After adjustment for age, body mass index, fasting plasma glucose,
diabetes treatment, systolic blood pressure, diastolic blood pressure,
hypertension treatment, serum cholesterol, serum high-density
lipoprotein cholesterol, prior cardiovascular disease, smoking, and
leisure time physical activity, higher cathepsin S was associated with
higher CRP (regression coefficient for 1 sd increase, 0.13; 95%
confidence interval 0.07-0.19; P < 0.001) and higher serum IL-6
(regression coefficient for 1 sd increase, 0.08; 95% confidence
interval 0.01-0.14; P = 0.02). These associations remained similar in
normal-weight participants (body mass index <25 kg/m(2), n = 375). In
longitudinal analyses, higher cathepsin S at baseline was associated
with higher serum CRP and IL-6 after 7 yr.
CONCLUSIONS:
These results provide additional evidence for the interplay between
cathepsin S and inflammatory activity and suggest that this
association is present also in normal-weight individuals in the
community. Jobs E, et al. J Clin Endocrinol Metab. 2010
Sep;95(9):4460-4. Epub 2010 Jul 7. |
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Code No.: SK00371-01
Size: 96 T
Price: $360.00 USD
Standard Range:15.6-1000 pg/ml
Sensitivity: 3 pg/ml
Sample Type: serum, plasma
Sample Volume: 100 uL
Dilution factor: 20~40
Intra CV: 4-6%
Inter CV: 8-10%
Protocol: PDF |
Name |
Code No. |
Size |
Price ($) |
Cathepsin S (Total) (Human) ELISA Kit |
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96 T |
360.00 |
References:
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