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Human Total Cathepsin S ELISA KIt
 
Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men
OBJECTIVE: Cathepsin S has been suggested provide a mechanistic link between obesity and atherosclerosis, possibly mediated via adipose tissue-derived inflammation. Previous data have shown an association between circulating cathepsin S and inflammatory markers in the obese, but to date, community-based reports are lacking. Accordingly, we aimed to investigate the association between serum levels of cathepsin S and markers of cytokine-mediated inflammation in a community-based sample, with prespecified subgroup analyses in nonobese participants.
METHODS: Serum cathepsin S, C-reactive protein (CRP), and IL-6 were measured in a community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men; mean age 71 years, n = 991). CRP and IL-6 were also measured at a reexamination after 7 yr.
RESULTS: After adjustment for age, body mass index, fasting plasma glucose, diabetes treatment, systolic blood pressure, diastolic blood pressure, hypertension treatment, serum cholesterol, serum high-density lipoprotein cholesterol, prior cardiovascular disease, smoking, and leisure time physical activity, higher cathepsin S was associated with higher CRP (regression coefficient for 1 sd increase, 0.13; 95% confidence interval 0.07-0.19; P < 0.001) and higher serum IL-6 (regression coefficient for 1 sd increase, 0.08; 95% confidence interval 0.01-0.14; P = 0.02). These associations remained similar in normal-weight participants (body mass index <25 kg/m(2), n = 375). In longitudinal analyses, higher cathepsin S at baseline was associated with higher serum CRP and IL-6 after 7 yr.
CONCLUSIONS: These results provide additional evidence for the interplay between cathepsin S and inflammatory activity and suggest that this association is present also in normal-weight individuals in the community.
Jobs E, et al. J Clin Endocrinol Metab. 2010 Sep;95(9):4460-4. Epub 2010 Jul 7.
Human Cathepsin is a new cardiovascular biomarker
 
Human Total Cathepsin S ELISA
Code No.: SK00371-01
Size: 96 T
Price: $360.00 USD
Standard Range:15.6-1000 pg/ml
Sensitivity: 3 pg/ml
Sample Type: serum, plasma
Sample Volume: 100 uL
Dilution factor: 20~40
Intra CV: 4-6%
Inter CV: 8-10%
Protocol: PDF
Name
Code No.
Size
Price ($)
Cathepsin S (Total)  (Human) ELISA Kit
96 T
360.00

References: