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Dipeptidyl Peptidase 4 (DPP4): A Novel Adipokine

Alternative name:

  • DPP4
  • CD26
Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome
OBJECTIVE Comprehensive proteomic profiling of the human adipocyte secretome identified dipeptidyl peptidase 4 (DPP4) as a novel adipokine. This study assessed the functional implications of the adipokine DPP4 and its association to the metabolic syndrome.
RESEARCH DESIGN AND METHODS Human adipocytes and skeletal and smooth muscle cells were used to monitor DPP4 release and assess the effects of soluble DPP4 on insulin signaling. In lean and obese subjects, depot-specific expression of DPP4 and its release from adipose tissue explants were determined and correlated to parameters of the metabolic syndrome.
RESULTS Fully differentiated adipocytes exhibit a substantially higher release of DPP4 compared with preadipocytes or macrophages. Direct addition of DPP4 to fat and skeletal and smooth muscle cells impairs insulin signaling. A fivefold higher level of DPP4 protein expression was seen in visceral compared with subcutaneous fat of obese patients, with no regional difference in lean subjects. DPP4 serum concentrations significantly correlated with adipocyte size. By using adipose tissue explants from lean and obese subjects, we observed a twofold increase in DPP4 release that strongly correlated with adipocyte volume and parameters of the metabolic syndrome and was decreased to the lean level after weight reduction. DPP4 released from adipose tissue correlated positively with an increasing risk score for the metabolic syndrome.
CONCLUSIONS DPP4 is a novel adipokine that may impair insulin sensitivity in an autocrine and paracrine fashion. Furthermore, DPP4 release strongly correlates with adipocyte size, potentially representing an important source of DPP4 in obesity. Therefore, we suggest that DPP4 may be involved in linking adipose tissue and the metabolic syndrome.
Daniela Lamers et al. Diabetes July 2011 vol. 60 no. 7 1917-1925
 
 
   
human DPPIV elisa kit
Human Soluble DPPIV ELISA
Code No.: SK00900-01
Size: 96 T
Price: $590.00 USD
Standard Range:31.2-2000 pg/ml
Sensitivity:15 pg/ml
Sample Type: EDTA plasma
Sample requres: 100uL per well (300 fold diluted samples)
IntraCV: 6-8%
InterCV: 10-12%
Protocol: PDF
human DPP4 recombinant
Human Soluble DPPIV His Tag
Code No.: 00900-03-50
Size: 50 ug
Price: $490.00 USD
Expression:HEK293 cells
Sequence:29-766
Tag: His Tag on C-terminus
Protein ID: NP_001926.2
MW: 92 KD
Purity: 95%
Endotoxin: less than 0.1 EU per ug protein

 

Name
Code No.
Size
Price ($)
DPPIV  (Human) ELISA Kit
96 T
590.00
DPPIV  (Human) Tag free (HEK293 cells)
00900-06-50
50 ug
690.00
DPPIV  (Human) Tag free (HEK293 cells)
00900-06-1000
1 mg
4600.00
DPPIV  (Human) His Tag (HEK293 cells)
00900-03-20
20 ug
360.00
DPPIV  (Human) His Tag (HEK293 cells)
00900-03-50
50 ug
490.00
DPPIV  (Human) His Tag (HEK293 cells)
00900-03-1000
1 mg
4200.00
DPPIV  (Human) Fc (HEK293 cells)
00900-04-50
50 ug
690.00
DPPIV  (Human) Fc (HEK293 cells)
00900-04-1000
1 mg
3900.00