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Fibroblast Growth Factor 1 (acidic) Recobinant, ELISA Antibody

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation, . Although FGF1 is known as a mitogenic factor, FGF1 knockout mice develop insulin resistance when stressed by a high-fat diet, suggesting a potential role in nutrient homeostasis. Here we show that parenteral delivery of a single dose of recombinant FGF1 (rFGF1) results in potent, insulin-dependent lowering of glucose levels in diabetic mice that is dose-dependent but does not lead to hypoglycaemia. Chronic pharmacological treatment with rFGF1 increases insulin-dependent glucose uptake in skeletal muscle and suppresses the hepatic production of glucose to achieve whole-body insulin sensitization. The sustained glucose lowering and insulin sensitization attributed to rFGF1 are not accompanied by the side effects of weight gain, liver steatosis and bone loss associated with current insulin-sensitizing therapies. We also show that the glucose-lowering activity of FGF1 can be dissociated from its mitogenic activity and is mediated predominantly via FGF receptor 1 signalling. Thus we have uncovered an unexpected, neomorphic insulin-sensitizing action for exogenous non-mitogenic human FGF1 with therapeutic potential for the treatment of insulin resistance and type 2 diabetes.
Jae Myoung Suh et al. Nature(2014)doi:10.1038/nature13540 Published online 16 July 2014
Anti Human FGF1/Acidic antibody paired for elisa development
Capture Detection
Clone 1B1
Clone 2C9
Clone 1B1
Clone 1B5
Clone 1B5
A00354-01-100
Clone 2C9
A00354-01-100
Fibroblast Growth Factor 1 (FGF-1) (acidic) (Human) ELISA Kit
Code No.: SK00354-01
Size: 96 T
Price: $360.00
Standard range:78-5000 pg/ml
Sensitivity: 10 pg/ml
Sample Type: serum, plasma
Intra-CV: 4-6%
Inter-CV: 8-12%
More info: Protocol
Code No.: 00354-01-100
Size: 100 ug
Price: $160.00
Protein ID:P05230
Gene ID: 2246
MW : 15.8 KD
Tag : 6x His Tag on N-Terminus
Expressed : E. Coli
More info: Data Sheet
  Anti Human FGF-1 Antibody
Code No.:A00354-01-100
Size: 100 ug
Price: $220.00
Antigen: humanFGF1, rec.
Ab Type: Polyclonal IgG
Host: Rabbit
Purification: Protein A
Specificity : H, R
Application : ELISA, IHC, WB
Positive Tissues :
Working Conc: IHC 2 ug/ml ; WB 1 ug/ml
Protocol: ABC
More info: Data Sheet
Human FGF Acidic Paired Antibodies
Capture Detection
Clone 1H5
Clone 1D11
Clone 1B1
Clone 2C9
Clone 2C9
Clone 2G5
Clone 1H5
Clone 2C9
Clone 1H5
Clone 2G5

 

Name
Code No.
Size
Price ($)
Fibroblast Growth Factor 1 (FGF-1) (acidic) (Human) ELISA Kit (serum) SK00354-01 96 T 360.00
Fibroblast Growth Factor 1 (FGF-1) (acidic) (Human) ELISA Kit (cell culture) SK00354-02 96 T 390.00
Fibroblast Growth Factor 1 (FGF-1) (acidic) (Human) ELISA Development Set (cell culture) SK00354-09 15 x 96 T 629.00
Fibroblast Growth Factor 1 (FGF-1) (acidic) (Human) ELISA Development Set (Cell culture) SK00354-06 5 x 96 T 299.00
       
Human FGF1 /Acidic FGF Recombinant
00354-01-1000
1 mg
inquire
Human FGF1 /Acidic FGF Recombinant
100 ug
160.00
Anti FGF1 (Human) IgG A00354-01-100 100 ug 220.00
Anti FGF-1 (Human) IgG Biotinylated (Detection) A00354-01-50B 50 ug 300.00
Anti FGF1 (Human) Monoclonal IgG (Clone1B1) (Capture) A00354-02-100 100 ug 300.00
Anti FGF1 (Human) Monoclonal IgG (Clone1H5) (Capture) A00354-03-100 100 ug 260.00
Anti FGF1 (Human) Monoclonal IgG (Clone 1D11) Biotinylated (Detection) A00354-09-50B 50 ug 360.00
Anti FGF1 (Human) Monoclonal IgG (Clone 1B10) A00354-04-100 100 ug 260.00
Anti FGF1 (Human) Monoclonal IgG (Clone 1B10) Biotinylated (Detection) A00354-04-50B 50 ug 360.00
Anti FGF1 (Human) Monoclonal IgG (Clone 2G5) A00354-05-100 100 ug 260.00
Anti FGF1 (Human) Monoclonal IgG (Clone 2C9) A00354-06-100 100 ug 260.00
Anti FGF1 (Human) Monoclonal IgG (Clone 2C9) Biotinylated (Detection) A00354-06-50B 50 ug 360.00