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FGF-21 (Human) ELISA KIT

FGF21 (Mouse/Rat) ELISA Kit

Mouse FGF-21 ELISA Kit SK00145-08 had been used by Dr. Leng Y on following research paper

FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers

Fibroblast growth factor-21 (FGF-21) is a new member of the FGF super-family and an important endogenous regulator of glucose and lipid metabolism. It has been proposed as a therapeutic target for diabetes and obesity. Its function in the central nervous system (CNS) remains unknown. Previous studies from our laboratory demonstrated that aging primary neurons are more vulnerable to glutamate-induced excitotoxicity, and that co-treatment with the mood stabilizers lithium and valproic acid (VPA) induces synergistic neuroprotective effects. This study sought to identify molecule(s) involved in these synergistic effects. We found that FGF-21 mRNA was selectively and markedly elevated by co-treatment with lithium and VPA in primary rat brain neurons. FGF-21 protein levels were also robustly increased in neuronal lysates and culture medium following lithium-VPA co-treatment. Combining glycogen synthase kinase-3 (GSK-3) inhibitors with VPA or histone deacetylase (HDAC) inhibitors with lithium synergistically increased FGF-21 mRNA levels, supporting that synergistic effects of lithium and VPA are mediated via GSK-3 and HDAC inhibition, respectively. Exogenous FGF-21 protein completely protected aging neurons from glutamate challenge. This neuroprotection was associated with enhanced Akt-1 activation and GSK-3 inhibition. Lithium-VPA co-treatment markedly prolonged lithium-induced Akt-1 activation and augmented GSK-3 inhibition. Akt-1 knockdown markedly decreased FGF-21 mRNA levels and reduced the neuroprotection induced by FGF-21 or lithium-VPA co-treatment. In addition, FGF-21 knockdown reduced lithium-VPA co-treatment-induced Akt-1 activation and neuroprotection against excitotoxicity. Together, our novel results suggest that FGF-21 is a key mediator of the effects of these mood stabilizers and a potential new therapeutic target for CNS disorders.
Leng Y., et al. Mol Psychiatry. 2015 Feb;20(2):215-23.
human fgf21
mouse fgf 21
 

human FGF-21 elisa kit

Human FGF21 ELISA
Code No.: SK00145-01
Size: 96 T
Price: $420.00 USD
Standard Range:15.6-2000 pg/ml
Sample Type:serum, EDTA plasma
Sample Volume: 100 uL
Dilution Factor:
Intra CV: 4%
Inter CV: 8%
Protocol: PDF
   
mouse fgf-21 elisa kit from aviscera
Mouse FGF21 ELISA
Code No.: SK00145-08
Size: 96 T
Price: $420.00 USD
Standard Range:15.6- 1000 pg/ml
caliberation: Mouse FGF-32 recombinant
Sample Type: Serum, EDTA plasma
Sample Volume: 100 uL
Dilution Factor:
Intra CV: 4%
Inter CV: 8%
Protocol: PDF
Rat serum or EDTA plasma samples cross-react with this mouse FGF-21 ELISA Kit
Mouse FGF21 ELISA
Code No.: SK00145-23
Size: 96 T
Price: $460.00 USD
Standard Range: 15.6-1000 pg/ml
Caliberation: Mouse FGF-32 recombinant
Specificity: Mouse, Rat
Sample Type: Serum, EDTA plasma
Sample Volume: 100 uL
Dilution Factor:
Intra CV: 4-6%
Inter CV: 8-12%
Protocol: PDF

Human FGF21 Recombinant
Code No.:00145-02-100
Size: 100 ug
Price: $300.00 USD
Gene ID: 26291
Protein ID: Q9NSA1
Sequence: Mature form
MW: 22KD
Tag: His tag
Source: E. Coli expressed
Purity: 95% in SDS-PAGE Gel
Formulation: PBS lyophilized
Storage: -20 oC ~ -70oC
Reconstitution: 100 uL
Data Sheet: PDF

mouse FGF21 recombinant

Human FGF19-21 Recombinant
Code No.:00145-08-100
Size: 100 ug
Price: $580.00 USD
Sequence: Chimeric Protein (FGF19(25-177)/FGF21 (177-209)
MW: 20KD
Tag: His tag
Source: E. Coli expressed
Purity: 95% in SDS-PAGE Gel
Formulation: PBS lyophilized
Storage: -20 oC ~ -70oC
Data Sheet: PDF

Anti Human FGF21 IgG
Code No.:00145-02-100
Size: 100 ug
Price: $200.00 USD
Host: Rabbit
Immunohen: Human FGF21, Rec
Antibody Type:Polyclonal IgG
Purification:Protein A affinity
Carry: free
Formulation: PBS lyophilized
Storage: -20 oC ~ -70oC
Data Sheet: PDF
Anti Mouse FGF21 IgG
Code No.:00145-03-100
Size: 100 ug
Price: $200.00 USD
Host: Rabbit
Immunohen:Mouse FGF21, Rec
Antibody Type:Polyclonal IgG
Purification:Protein A affinity
Carry: free
Formulation: PBS lyophilized
Storage: -20 oC ~ -70oC
Data Sheet: PDF
Anti Human FGF21 IgG
Code No.:00145-02-100
Size: 100 ug
Price: $200.00 USD
Host: Rabbit
Immunohen: Human FGF21, Rec
Antibody Type:Polyclonal IgG
Purification:Protein A affinity
Carry: free
Formulation: PBS lyophilized
Storage: -20 oC ~ -70oC
Data Sheet: PDF
fgf21 western blot
Anti Mouse FGF21 IgG
Code No.:00145-03-100
Size: 100 ug
Price: $200.00 USD
Host: Rabbit
Immunohen:Mouse FGF21, Rec
Antibody Type:Polyclonal IgG
Purification:Protein A affinity
Carry: free
Formulation: PBS lyophilized
Storage: -20 oC ~ -70oC
Data Sheet: PDF

 

 

Name
Code No.
Size
Price ($)
Human FGF21 ELISA Kit
96 T
420.00
Human FGF21 ELISA Kit
SK00145-02
96 T
420.00
Mouse/Rat FGF21 ELISA Kit
96 T
420.00
Mouse FGF21 ELISA Kit
96 T
420.00
Mouse FGF21 ELISA Kit
96 T
460.00
Human FGF21 ELISA Set ( 10 x 96 T) (components)
SK00145-10
Set
620.00
Mouse FGF21 ELISA Set (10 x 96 T) (components)
SK00145-20
Set
620.00
Human FGF21 His Tag Recombinant
00145-02-10
10 ug
65.00
Human FGF21 His Tag Recombinant
00145-02-20
20 ug
120.00
Human FGF21 His Tag Recombinant
00145-02-50
50 ug
195.00
Human FGF21 His Tag Recombinant
100 ug
300.00
Human FGF21 His Tag Recombinant
00145-02-1000
1 mg
1500.00
Human FGF19-21 Chimera
100 ug
580.00
Mouse FGF-21 Recombinant
100 ug
300.00
Mouse FGF-21 His Tag Recombinant
00145-03-10
10 ug
65.00
Mouse FGF-21 His Tag Recombinant
00145-03-20
20 ug
120.00
Mouse FGF-21 His Tag Recombinant
00145-03-50
50 ug
195.00
Mouse FGF-21 Recombinant
00145-03-500
500 ug
1200.00
Mouse FGF-21 His Tag Recombinant
00145-03-1000
1 mg
1500.00
anti FGF-21 (Human) Monoclonal Antibody
100 ug
395.00
anti FGF-21 (Human) Monoclonal Antibody
A00145-01-25
25 ug
125.00
Anti FGF-21 (Human) IgG
100 ug
200.00
Anti FGF-21 (Human) IgG
A00145-02-25
25 ug
80.00
Anti FGF-21 (Mouse) IgG
100 ug
220.00
anti FGF-21 (Human) Monoclonal Antibody
100 ug
395.00
anti FGF-21 (Human) Monoclonal Antibody
100 ug
260.00
anti FGF-21 (Human) Monoclonal Antibody
100 ug
260.00
anti FGF-21 (Human) Monoclonal Antibody
100 ug
260.00
anti FGF-21 (Human) Monoclonal Antibody
100 ug
260.00
anti FGF-21 (Human) Monoclonal Antibody
100 ug
260.00
anti FGF-21 (Human) Monoclonal Antibody
100 ug
260.00
anti FGF-21 (Human) Monoclonal Antibody
100 ug
260.00
anti FGF-21 (Human) Monoclonal Antibody
100 ug
260.00