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Glia Maturation Factor Gamma (GMF-G)

Alternative name:

  • GMF-Gamma
Actin cytoskeleton reorganization is a fundamental process for actin-based cellular functions such as cytokinesis, phagocytosis, and chemotaxis. Regulating actin cytoskeleton reorganization is therefore an attractive approach to control endothelial and inflammatory cells function and to treat cardiovascular diseases. Here, we identified glia maturation factor-gamma (GMFG) as a novel factor in actin cytoskeleton reorganization and is expressed preferentially in microvascular endothelial and inflammatory cells. During mouse embryogenesis, GMFG was expressed predominantly in blood islands of the yolk sac, where endothelial and hematopoietic cells develop simultaneously. In endothelial cells, GMFG was colocalized with F-actin in membrane ruffles and was associated with F-actin assessed by actin co-sedimentation assay. Interestingly, GMFG was phosphorylated at N-terminal serine, and its phosphorylation was enhanced by coexpression of dominant active Rac1 and Cdc42. Furthermore, a pseudophosphorylated form of GMFG (GMFG-S2E) demonstrated higher association with F-actin. Stable expression of GMFG-S2E remarkably enhanced stimulus-responsive lamellipodia and subsequent membrane ruffle formation in HeLa cells presumably through its interaction with Arp2/3 complex. Expression of GMFG enhanced actin-based cellular functions such as migration and tube-formation in endothelial cells. Moreover, we found that GMFG expression was significantly increased in a cardiac ischemia/reperfusion model where inflammation and angiogenesis take place actively. Taken together, our findings define a novel pathway in the regulation of actin-based cellular functions. Regulating GMFG function may provide a novel approach to modulate the pathophysiology of cardiovascular diseases.
Ikeda K, et al. Circ Res. 2006 Aug 18;99(4):424-33. Epub 2006 Jul 27.
anti human GMF gamma monoclonal antibody Anti Human GMF-G Monoclonal Antibody
Code No.: A00676-02-100
Size: 100 ug
Price: $260.00 USD
Host: Mouse
Antigen: human GMF-G Rec.
Ab Type: Monoclonal
Clone No.: 3H8H11C2
Purification: Protein A
Applications: E, WB
Working Dilution: 2 ug/ml)
Data Sheet: PDF
anti human GMF gamma monoclonal antibody Anti Human GMF-G Monoclonal Antibody
Code No.: A00676-03-100
Size: 100 ug
Price: $260.00 USD
Host: Mouse
Antigen: human GMF-G Rec.
Ab Type: Monoclonal
Clone: 1B6C6D2F3
Purification: Protein A
Applications: E, WB
Working Dilution: 2 ug/ml)
Data Sheet: PDF
anti human GMF-G antibody
Anti Human GMF-G IgG
Code No.: A00676-01-100
Size: 100 ug
Price: $220.00 USD
Host: Rabbit
Antigen: human GMF-G Rec.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC
Working Dilution: 2 ug/ml)
Data Sheet: PDF
Human GMF-G Recombinant
Code No.: 00676-01-100
Size: 100 ug
Price: $360.00 USD
Protein ID:O60234
Gene ID: 9535
MW:15.5 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 80%
Data Sheet: PDF

 

Name
Code No.
Size
Price ($)
GMF-G (Human) recombinant
00676-01-10
10 ug
80.00
GMF-G (Human) recombinant
00676-01-50
50 ug
250.00
GMF-G (Human) recombinant
100 ug
360.00
GMF-G (Human) recombinant
00676-01-1000
1000 ug
3200.00
Rabbit Anti GMF-G (Human) IgG
100 ug
220.00
Rabbit Anti GMF-G (Human) IgG
5 mL
200.00
Anti MGF-G (Human) Monoclonal Antibody A00676-02-100 100 ug 260.00
Anti MGF-G (Human) Monoclonal Antibody A00676-03-100 100 ug 260.00
GMF-G Western Blot Kit WK00676-02 5-runs 560.00
GMF-G Western Blot Kit WK00676-03 5 runs 560.00