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Soluble Heparin-Binding EGF-like Growth Factor (HB-EGF) ELISA Kit, Antibody, Recombinant
Alternative name(s): Diphtheria toxin receptor
HBEGF and other members of the EGF family are synthesized as transmembrane proteins (e.g., proHBEGF). Pro-HB-EGF is cleaved by metallo-proteinases to release the shedding soluble form of HB-EGF. (sHB-EGF). Soluble HB-EGF is free to bind and activate receptors (HER1 and HER4) on the same cell (autocrine) or distant cells (paracrine). Soluble HB-EGF is a potent mitogen and chemoattractant for a number of cell types including vascular smooth muscle cells, fibroblasts and keratinocytesIt but not endothelial cells. Soluble HB-EGF is a natural ligand for EGF receptors (HER1 & HER4) with higher affinity than EGF itself. sHB-EGF requires heparan sulfate proteoglycan (HSPG) as a cofactor for binding to its receptors, HER1 and HER4.
 
The epidermal growth factor (EGF)-ErbB signaling network is composed of multiple ligands of the EGF family and four tyrosine kinase receptors of the ErbB family. In higher vertebrates, these four receptors bind a multitude of ligands. Ligandbinding induces the formation of various homo- and heterodimers of ErbB,potentially providing for a high degree of signal diversity. ErbB receptors andtheir ligands are expressed in a variety of tissues throughout development.Recent advances in gene targeting strategies in mice have revealed that theEGF-ErbB signaling network has fundamental roles in development, proliferation,differentiation, and homeostasis in mammals. The heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to andactivates the EGF receptor (EGFR/ErbB1) and ErbB4. Recent studies using severalmutant mice lacking HB-EGF expression have revealed that HB-EGF has a criticalrole in normal heart function and in normal cardiac valve formation inconjunction with ErbB receptors. HB-EGF signaling through ErbB2 is essential for the maintenance of homeostasis in the adult heart, whereas HB-EGF signalingthrough EGFR is required during cardiac valve development. In this review, weintroduce and discuss the role of ErbB receptors in heart function anddevelopment, focusing on the physiological function of HB-EGF in these processes.
Iwamoto R, Mekada E. Cell Struct Funct. 2006;31(1):1-14.
The establishment of pregnancy requires an intimate physical interaction and a molecular dialogue between the conceptus and the maternal reproductive tract that commences at implantation and continues until the placenta is formed and fully functional. Failure of the regulatory processes that ensure the fidelity of this relationship can precipitate a catastrophic pregnancy loss. One of the earliest identified molecular mediators of blastocyst implantation is heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF), which signals between the endometrium and implanting trophoblast cells to synchronize their corresponding developmental programs. HBEGF expression by trophoblast cells of the developing placenta appears to regulate extravillous differentiation and provide cytoprotection in a sometimes-hostile environment. This versatile member of the EGF signaling system will be examined in light of its associations with key events during early pregnancy.

Jessmon P, Leach RE, Armant DR. Diverse functions of HBEGF during pregnancy. Mol Reprod Dev. 2009 Dec;76(12):1116-27.

Human soluble HBEGF ELISA Kit SK00470-02 Human Soluble HBEGF ELISA Kit
Code No.: SK00470-02
Size: 96 T
Price: $390.00 USD
Standard range:312 -20000 pg/ml
Sensitivity: 70 pg/ml
Sample Type: serum, plasma
sample require: 50 uL per well
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet: PDF

human HBEGF recombinant is available in www.adipobioscience.com

Human HBEGF Recombinant
Code No.: 00470-01-100
Size: 100 ug
Price: $360.00 USD
Protein ID:Q99075
Gene ID: 1839
MW: 9 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 90%
Data Sheet: PDF

anti human HBEGF antibody for western blot analysis

Anti Human HBEGF IgG
Code No.: A00470-01-100
Size: 100 ug
Price: $220.00 USD
Host: Rabbit
Antigen: human HBEGF Rec.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC, WB
Working Dilution: WB 1: 500 (2 ug/ml)
Data Sheet: PDF

 

Name
Code No.
Size
Price ($)
Soluble HB-EGF (Human) ELISA Kit SK00470-02 96 T 390.00
Soluble HB-EGF (Human), Rec.
10 ug
60.00
Soluble HB-EGF (Human), Rec.
00470-01-50
50 ug
160.00
Soluble HB-EGF (Human), Rec.
100 ug
260.00
Soluble HB-EGF (Human), Rec.
00470-01-1000
1 mg
2000.00
Soluble HB-EGF (Human), Rec. Biotinylated
00470-01-50B
50 ug
360.00
Soluble HB-EGF (Human), Rec. FITC Conjugated
00470-01-50F
50 ug
360.00
Soluble HB-EGF (Human), Rec. Cy3 Conjugated
00470-01-50C3
50 ug
460.00
Rabbit Anti Soluble HB-EGF (H) IgG
100 ug
220.00
Rabbit Anti Soluble HB-EGF (H) IgG , Biotinylated
50 ug
390.00
Rabbit Anti Soluble HB-EGF (H) IgG , Cy3 Conjugated
A00470-01-50C3
50 ug
460.00
Anti HBEGF (Human) Monoclonal Antibody
100 ug
260.00
Anti HBEGF (Human) Monoclonal Antibody
100 ug
260.00