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Insulin-like Growth Factor Binding Protein-3(IGFBP-3) ELISA
A Biomarker for Diabetes and Lipid Metabolism
Insulin-like Growth Factor 1 ELISA Kit

Alternative name:

  • IGFBP-3
  • growth hormone-dependent binding protein
  • acid stable subunit of the 140 K IGF complex

Kim MS, Lee DY. J Pediatr Endocrinol Metab. 2014 May 13

Cross-sectional and longitudinal relation of IGF1 and IGF-binding protein 3 with lipid metabolism

BACKGROUND: Previous intervention studies in patients with GH disorders suggested an impact of IGF1 and IGF-binding protein 3 (IGFBP3) on lipid metabolism, whereas population-based studies revealed conflicting results. Therefore, we aimed to assess the cross-sectional and longitudinal associations between IGF1 or IGFBP3 serum levels and lipids (total, LDL, or HDL cholesterol and triglycerides) in a large-scale study.
METHODS: Data of 2935 subjects (1356 women) from the population-based Study of Health in Pomerania (SHIP) were used. ANOVA, quantile regression, and logistic regression models adjusted for age, waist circumference, physical activity, and alcohol consumption were performed.
RESULTS: In cross-sectional analyses, we detected that IGF1 and IGFBP3 levels were positively related to total and LDL cholesterol and inversely related to HDL cholesterol in both sexes. Furthermore, IGFBP3 levels showed a positive relationship to triglycerides. In total, IGFBP3 levels were more strongly associated to lipids than IGF1. In longitudinal analysis, we found no influence of baseline IGF1 or IGFBP3 serum concentration on incidentally elevated or reduced lipid levels. However, the positive relationship between IGFBP3 and incidentally elevated triglycerides barely missed statistical significance in women.
CONCLUSION:The present study showed strong cross-sectional associations between IGF1 or IGFBP3 and lipids, whereas no longitudinal relationships were revealed. Therefore, our findings suggest IGF1 and IGFBP3 as a risk marker rather than a risk factor for alterations in lipid metabolism. Further studies are needed to elucidate the mechanisms underlying the association between the GH/IGF axis and lipid metabolism.
Eggert ML et al. Eur J Endocrinol. 2014 Jul;171(1):9-19
human igfbp-3 elisa kit from aviscera bioscience
Human IGFBP-3 ELISA
Code No.: SK00053-01
Size: 96 T
Standard Range:31-2000 pg/ml
Sensitivity: 15 pg/ml
Sample Type: serum, plasma
Sample Volume: 100 uL of diluted samples
Dilution Factor: 250-500
Intra CV: 4-6%
Inter CV: 8-10%
Protocol: PDF

human IGFBP3 elisa kit

Human IGFBP-3 ELISA
Code No.: SK00053-02
Size: 96 T
Standard Range:125-8000 pg/ml
Sensitivity: 15 pg/ml
Sample Type: serum, plasma
Sample Volume: 100 uL of diluted samples
Dilution Factor: 250-500
Intra CV: 4-6%
Inter CV: 8-10%
Protocol: PDF
  Human IGFBP1 ELISA
Code No.: SK00051-01
Size: 96 T
Standard Range:125-8000 pg/ml
Sensitivity: 30 pg/ml
Specificity: Human IGFBP
Sample Type: serum, plasma (all samples require pretreatment)
Sample Volume: 100 uL of pretreated samples
Dilution Factor: pretreatment
Intra CV: 4-6%
Inter CV: 8-10%
Protocol: PDF

 

Name
Code No.
Size
Human IGFBP-3 ELISA Kit
96 T
Human IGFBP-3 ELISA Kit
96 T
Human IGFBP-1 ELISA Kit
96 T