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IL-1F9 (Human ) ELISA Kit,

Recombinant, Antibody

Other names:
  • IL-1H1,
  • IL-1RP2,
  • IL-1ε
Functions: Agonist via the IL-1Rrp2 receptor. Increases IL-6, IL-8 production in epithelial cells
 

Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungs

Interleukin-1 (IL-1) is a proinflammatory cytokine that signals through the Type I IL-1 receptor (IL-1RI). Novel IL-1-like cytokines were recently identified. Their functions in lung disease remain unclear. Interleukin-1 family member-9 (IL-1F9) is one such IL-1-like cytokine, expressed in the lungs of humans and mice. IL-1F9 signals through IL-1 receptor-related protein 2 (IL-1Rrp2/IL-1RL2), which is distinct from IL-1RI. We sought to determine if IL-1F9 acts as a proinflammatory cytokine in lung disease. IL-1F9 protein was increased in lung homogenates of house dust mite-challenged A/J mice compared with controls, and expression was seen in airway epithelial cells. The intratracheal administration of recombinant mouse IL-1F9 increased airway hyperresponsiveness and induced neutrophil influx and mucus production, but not eosinophilic infiltration in the lungs of mice. In addition, IL-1α protein levels in bronchoalveolar lavage fluid, chemokines, and chemokine-receptor mRNA expression in the lungs were increased after the instillation of intratracheal IL-1F9. Consistent with these changes, NF-κB transcription factor activity was increased in the lungs of mice challenged with IL-1F9 and in a macrophage cell line treated with IL-1F9. These data suggest that IL-1F9 is upregulated during inflammation, and acts as a proinflammatory cytokine in the lungs.
Ramadas RA, et al. Am J Respir Cell Mol Biol. 2011 Feb;44(2):134-45. Epub 2010 Mar 18

IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression

IL-1F6, IL-1F8, and IL-1F9 and the IL-1R6(RP2) receptor antagonist IL-1F5 constitute a novel IL-1 signaling system that is poorly characterized in skin. To further characterize these cytokines in healthy and inflamed skin, we studied their expression in healthy control, uninvolved psoriasis, and psoriasis plaque skin using quantitative RT-PCR and immunohistochemistry. Expression of IL-1F5, -1F6, -1F8, and -1F9 were increased 2 to 3 orders of magnitude in psoriasis plaque versus uninvolved psoriasis skin, which was supported immunohistologically. Moreover, treatment of psoriasis with etanercept led to significantly decreased IL-1F5, -1F6, -1F8, and -1F9 mRNAs, concomitant with clinical improvement. Similarly increased expression of IL-1F5, -1F6, -1F8, and -1F9 was seen in the involved skin of two mouse models of psoriasis. Suggestive of their importance in inflamed epithelia, IL-1α and TNF-α induced IL-1F5, -1F6, -1F8, and -1F9 transcript expression by normal human keratinocytes. Microarray analysis revealed that these cytokines induce the expression of antimicrobial peptides and matrix metalloproteinases by reconstituted human epidermis. In particular, IL-1F8 increased mRNA expression of human β-defensin (HBD)-2, HBD-3, and CAMP and protein secretion of HBD-2 and HBD-3. Collectively, our data suggest important roles for these novel cytokines in inflammatory skin diseases and identify these peptides as potential targets for antipsoriatic therapies.
Johnston A, et al. J Immunol. 2011 Feb 15;186(4):2613-22. Epub 2011 Jan 17.
 
Human IL-1F9 ELISA kit enables to detect circulating IL-1F9
EDTA Plasma Samples IL-1F9 (pg/ml)
1 1912.487
2 745.528
3 578.149
4 721.179
5 157.441
6 213.585
7 477.373
8 122.768
9 316.426
10 29.904
11 168.816
12 15.954
13 446.726
14 374.331
15 389.958
 
human IL-1F9 ELISA Kit from adipo bioscience
Human IL-1F9 ELISA
Code No.: SK00739-01
Size: 96 T
Price: $420.00 USD
Standard Range:156-5000 pg/ml
Dynamic Range:156-5000 pg/ml
Sensitivity: 12 pg/ml
Sample Type: serum, EDTA plasma
Sample requres: 200 ul, 100 ul per well
IntraCV: 6-8%
InterCV: 10-12%
Protocol: PDF
anti human IL-1F9 antibody from aviscera bioscience Anti Human IL1F9 IgG
Code No.: A00739-01-100
Size: 100 ug
Price: $260.00 USD
Host: Rabbit
Antigen: ECD of human IL-1F9 Rec.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC
Working Dilution: IHC 1: 200 (5 ug/ml)
Data Sheet: PDF

Human IL-1F9 Recombinant
Code No.: 00739-01-100
Size: 100 ug
Price: $360.00 USD
Protein ID:Q9NZH8
Gene ID: 56300
MW: 27 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 90%
Data Sheet: PDF

 

Name
Code No.
Size
Price ($)
Human IL-1F9/IL-36G ELISA Kit SK00739-01 96 T 420.00
Human IL-1F9/IL-36G, recombinant
10 ug
178.00
Human IL-1F9/IL-36G, recombinant
50 ug
280.00
Human IL-1F9/IL-36G, recombinant
100 ug
360.00
Human IL-1F9/IL-36G, recombinant
1 mg
3200.00
Human IL-1F9/IL-36G Biotinylated
50 ug
420.00
Anti Human IL-1F9/IL-36G IgG
100 ug
220.00
Anti Human IL-1F9/IL-36G IgG Biotinylated
50 ug
420.00
Anti Human IL-1F9/IL-36G Monoclonal IgG
100 ug
260.00
Anti Human IL-1F9/IL-36G Monoclonal IgG Biotinylated
50 ug
420.00
Anti Human IL-1F9/IL-36G Monoclonal IgG
100 ug
260.00
Anti Human IL-1F9/IL-36G Monoclonal IgG
100 ug
260.00
Anti Human IL-1F9/IL-36G Monoclonal IgG
100 ug
260.00
Anti Human IL-1F9/IL-36G Monoclonal IgG
100 ug
260.00
Anti Human IL-1F9/IL-36G Monoclonal IgG
100 ug
260.00
Anti Human IL-1F9/IL-36G Monoclonal IgG
100 ug
260.00
Anti Human IL-1F9/IL-36G Monoclonal IgG
100 ug
260.00
Anti Human IL-1F9/IL-36G Monoclonal IgG
100 ug
260.00