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Interleukin 8 (IL-8) ELISA
A Ligand for CXCR1 and CXCR2

Alternative name:

  • CXCL8
  • beta endothelial cell-derived neutrophil activating peptide (NAP-1)
  • lung giant cell carcinoma-derived chemotactic protein
Background. Immune reconstitution inflammatory syndrome (IRIS) reflects an aberrant immune response that can develop in HIV-infected patients initiating antiretroviral therapy (ART). Its pathogenesis remains unclear.Methods. We performed a nested case-control study using specimens from ACTG A5164. We compared plasma biomarkers and T-cell subsets in 19 IRIS and 39 control participants at study entry, ART initiation, and IRIS and used conditional logistic regression to develop IRIS predictive models. We evaluated corticosteroids' effects on biomarker levels.Results. Eleven and eight participants developed paradoxical and unmasking IRIS, respectively, none while still receiving corticosteroids. Compared to controls, cases displayed elevations at study entry in IL-8, Th1 (IL-2, IFN-γ, TNF) and Th17 (IL-17) cytokine levels that persisted through ART initiation and IRIS. In logistic regression, baseline higher IFN-γ and TNF were strong predictors of IRIS. Participants who received corticosteroids and later developed IRIS had marked increases in IL-6, IL-8, and IFN-γ at the time of IRIS. T-cell activation markers did not differ in cases and controls prior to ART but were increased in cases at the time of IRIS.Conclusions. Increased IL-8, Th1 and Th17 cytokine levels in IRIS patients precede ART initiation and could help identify patient populations at higher risk for IRIS.
 
   
Human IL-8 ELISA Kit
Code No.: SK00289-02
Size: 96 T
Price: $360.00 USD
Standard range:7.8-250 pg/ml
Sensitivity: 2-3 pg/ml
Sample Type: serum, plasma, cell cultures
Sample require:100 ul per well
Intra-CV: 4-8%
Inter-CV: 8-10%
Data Sheet: PDF
 

 

Name
Code No.
Size
Price ($)
Interleukin 8 (IL-8) (Human) ELISA Kit SK00289-02 96 T 360.00
IL-8 (Human) Rec 00289-01-100 100 ug 360.00
Anti IL-8 (Human) ELISA kit A00289-01-100 100 ug 220.00