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Meteorin-like (METRNL) ELISA, Antibody, Recombinant
Cometin (Human) ELISA,Antibody, Recombinant
Subfatin (Human) ELISA , Antibody, Recombinant
  • Meteorin, Glial Cell Differentiation Regulator-Like
  • Meteorin like
  • METRNL
  • Cometin
  • subfatin
human metrnl elisa kit from aviscera bioscience for human samples assay
 
 
human meteorin -like protein elisa kit sk00478-02 from aviscera bioscience
Meteorin-Like (METRNL) ELISA KIt
Code No.: SK00478-02
Size: 96 T
Price:
Standard range:0.977-125 ng/ml
Sensitivity:150 pg/ml
Sample Type: serum, plasma
Sample require: 100 uL per well
Intra-CV:6-8%
Inter-CV: 8-12% 
Protocol: PDF
Meteorin-Like (METRNL) ELISA KIt
Code No.: SK00478-06
Size: 96 T
Price:
Standard range:3.9-250 ng/ml
Sensitivity:500 pg/ml
Sample Type: serum, plasma
Sample require: 100 uL per well
Intra-CV:6-8%
Inter-CV: 8-12% 
Protocol: PDF

human meteorin like protein from aviscera bioscience

Human Meteorin-Like (METRNL) Recombinant
Code No.: 00478-01-100
Size: 100 ug
Price: $390.00 USD
Protein ID:NP_001004431
Gene ID: NM_001004431
MW: 46 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF
anti human metrnl igg a00478-01-100 from aviscera bioscience
Anti Meteorin -Like (METRNL)(Human) IgG
Code No.: A00478-01-100
Size: 100 ug
Price: $290.00 USD
Host :Rabbit
Antigen: Human METRNL
Specificity:Human
Antibody Type:Purified IgG
Purification: Protein A affinity
Application: E, IHC
Data Sheet: PDF
mouse meteorin like protein recombinant from aviscera bioscience
Mouse Meteorin-Like (METRNL) Recombinant
Code No.: 00478-03-100
Size: 100 ug
Price: $390.00 USD
Protein ID:NP_659046
Gene ID: NM_144797
MW: 32 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF
  Human Meteorin Recombinant
Code No.: 00423-01-100
Size: 100 ug
Price: $390.00 USD
Protein ID:NP_076947
Gene ID: NM_024042
MW: 32 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF
  Anti Meteorin -Like (METRNL)(Mouse, Rat) IgG
Code No.: A00478-05-100
Size: 100 ug
Price: $390.00 USD
Host :Goat
Antigen: mouse METRNL
SpecificityMouse, Rat
Antibody Type:Purified IgG
Purification: Antigen affinity
Application: WB (1-4 ug/ml)
Data Sheet: PDF

 

Name
Code No.
Size
Price ($)
Meteorin-Like (METRNL)/Sufatin (Human) ELISA Kit
96 T
460.00
Meteorin-Like (METRNL)/Sufatin (Human) rec
00478-01-10
10 ug
100.00
Meteorin-Like (METRNL)/Sufatin (Human) rec
50 ug
260.00
Meteorin-Like (METRNL)/Sufatin (Human) rec
100 ug
390.00
Meteorin-Like (METRNL)/Sufatin (Human) rec
00478-01-1000
1000 ug
inquire
Meteorin-Like (METRNL)/Sufatin (Human) rec, Biotinylated
00478-01-50B
50 ug
420.00
Meteorin-Like (METRNL)/Sufatin (Human) rec, Cy3
00478-01-50C3
50 ug
490.00
Meteorin-Like (METRNL)/Sufatin (Human) rec, FAM
00478-01-50FAM
50 ug
460.00
Meteorin-Like (METRNL)/Sufatin (Mouse) rec
100 ug
390.00
Meteorin-Like (METRNL) (Mouse) rec, Biotinylated
00478-03-50B
50 ug
420.00
Anti Meteorin-Like (METRNL) (Human) IgG
100 ug
290.00
Anti Meteorin-Like (METRNL) (Human) IgG, Biotinylated
50 ug
360.00
Anti Meteorin-Like (METRNL) (Human) Monoclonal Antibody
100 ug
350.00
Meteorin (METRN) (Human) rec
100 ug
390.00
Anti Meteorin-Like (METRNL) (Mouse, Rat) IgG for WB
100 ug
390.00
       
       
       

 

human METRNL aviscera bioscience
 
mouse metrnl aviscera bioscience

 

Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo

Neurotrophic factors are secreted proteins responsible for migration, growth and survival of neurons during development, and for maintenance and plasticity of adult neurons. Here we present a novel secreted protein named Cometin which together with Meteorin defines a new evolutionary conserved protein family. During early mouse development, Cometin is found exclusively in the floor plate and from E13.5 also in dorsal root ganglions and inner ear but apparently not in the adult nervous system. In vitro, Cometin promotes neurite outgrowth from dorsal root ganglion cells which can be blocked by inhibition of the Janus or MEK kinases. In this assay, additive effects of Cometin and Meteorin are observed indicating separate receptors. Furthermore, Cometin supports migration of neuroblasts from subventricular zone explants to the same extend as stromal cell derived factor 1a. Given the neurotrophic properties in vitro, combined with the restricted inner ear expression during development, we further investigated Cometin in relation to deafness. In neomycin deafened guinea pigs, two weeks intracochlear infusion of recombinant Cometin supports spiral ganglion neuron survival and function. In contrast to the control group receiving artificial perilymph, Cometin treated animals retain normal electrically-evoked brainstem response which is maintained several weeks after treatment cessation. Neuroprotection is also evident from stereological analysis of the spiral ganglion. Altogether, these studies show that Cometin is a potent new neurotrophic factor with therapeutic potential.
Jørgensen JR et al. Exp Neurol. 2012 Jan;233(1):172-81. doi: 10.1016/j.expneurol.2011.09.027. Epub 2011 Oct 2.
 

Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression

AIMS: Adipose tissue releases adipokines that play important roles in metabolic and cardio-cerebro-vascular homeostasis. This study was to discover novel adipokines using caloric restriction model.
METHODS:Adipokine candidates were captured by gene array and bioinformatics analysis and verified by preparation of recombinant protein and antibody.
RESULTS: We established a potential secreted protein database containing 208 genes and identified a novel adipokine, Subfatin, that was the highest expressed in subcutaneous fat of both rodents and humans among 15 detected tissues. The secreted mammalian Subfatin was a glycosylated protein. Subfatin was located diffusely throughout the adipose tissue except lipid droplets, with comparable expression between adipocytes and stromal cells, but much lower expression in macrophages than adipocytes. Subfatin was downregulated in white adipose tissue of caloric restriction rats, whereas dramatically upregulated during white adipocyte differentiation as well as in white adipose tissue of diet-induced obese mice. Subfatin was annotated as Meteorin-like (Metrnl) in public databases, a similar transcript of Meteorin (Metrn, also known as glial cell differentiation regulator). Meteorin displayed a brain-specific expression and was scarce in various adipose tissues, in contrast to the tissue expression patterns of Subfatin.
CONCLUSIONS:Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin
Li ZY et al. CNS Neurosci Ther. 2014 Apr;20(4):344-54. doi: 10.1111/cns.12219. Epub 2014 Jan 7

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

Exercise training benefits many organ systems and offers protection against metabolic disorders such as obesity and diabetes. Using the recently identified isoform of PGC1-α (PGC1-α4) as a discovery tool, we report the identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure. Increasing circulating levels of Metrnl stimulates energy expenditure and improves glucose tolerance and the expression of genes associated with beige fat thermogenesis and anti-inflammatory cytokines. Metrnl stimulates an eosinophil-dependent increase in IL-4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Importantly, blocking Metrnl actions in vivo significantly attenuates chronic cold-exposure-induced alternative macrophage activation and thermogenic gene responses. Thus, Metrnl links host-adaptive responses to the regulation of energy homeostasis and tissue inflammation and has therapeutic potential for metabolic and inflammatory diseases.
Rao RR et al. Cell. 2014 Jun 5;157(6):1279-91. doi: 10.1016/j.cell.2014.03.065.