AVISCERA BIOSCIENCE  
AVISCERA BIOSCIENCE  
line decor
  HOME  ::  
line decor
   
 

Total Matrix Metalloproteinase-3 (MMP-3) ELISA KIT

 

Variations in matrix metalloproteinase-1, -3, and -9 genes and the risk of acute coronary syndrome and coronary artery disease in the Chinese Han population

OBJECTIVES: Matrix metalloproteinases (MMPs) are a group of endopeptidases involved in the pathogenesis of atherosclerosis, and MMP gene polymorphisms may contribute toward the risk of coronary heart disease. Within this context, our aim was to examine whether MMP1, MMP3, and MMP9 gene polymorphisms are associated with susceptibility to acute coronary syndrome (ACS) or angiographic coronary artery disease (CAD).
METHODS: The MMP1 -519 A/G, MMP3 -1171 5A/6A, and MMP9 -1562 C/T polymorphisms were evaluated in 1574 individuals. Genotypes of patients with ACS (n=660) and angiographically defined CAD (n=382) were compared with ACS-free (n=914) and non-CAD controls (n=466).
RESULTS: The MMP3 5A allele occurred at a higher frequency in patients with ACS than in ACS-free individuals (P=0.001). Logistic regression analysis showed that the 5A/5A genotype of MMP3 was associated with a significantly increased risk of ACS [adjusted odds ratio (OR)=2.297, 95% confidence interval (CI)=1.105-4.775, P=0.026, 5A/5A vs. 6A/6A]. The CT and TT variant genotypes of MMP9 were associated with the occurrence of CAD (adjusted OR=1.425, 95% CI=1.045-1.943, P=0.025, CT+TT vs. CC). None of the MMP1 -519 A/G polymorphisms was associated with ACS or CAD. Because of linkage disequilibrium, MMP1 and MMP3 polymorphisms were combined on chromosome 11q22.3, and the 5A-1171-G-519 haplotype had a genetic risk factor for ACS (OR=1.505, 95% CI=1.219-1.857, P=0.00013), whereas the 6A-1171-G-519 haplotype had a decreased risk of ACS (OR=0.815, 95% CI=0.677-0.981, P=0.03).
CONCLUSION: Taken together, the present findings indicate that genetic variations in MMP3 and MMP9 genes may be useful genetic markers for determining susceptibility to CAD in the Chinese Han population.
xU x., ET AL. Coron Artery Dis. 2013 Jan 30. [Epub ahead of print]
Human Total MMP3ELISA Kit
Code No.: SK00162-02
Size: 96 T
Price:
Standard Range:31-2000 p g/mL
Sample Type: cell cultures, serum, plasma
Sample require: 200 uL
Intra-CV: 4-8%
Inter-CV: 6-10
Protocol: PDF
human MMP9 elisa kit from aviscera bioscience
Human MMP9(Total) ELISA Kit
Code No.: SK00160-06
Size: 96 T
Price:
Standard Range:31-2000 p g/mL
Sample Type: cell cultures, serum, plasma
Sample require: 200 uL
Intra-CV: 4-8%
Inter-CV: 6-10
Protocol: PDF
Human Total MMP8 ELISA Kit
Code No.: SK00159-01
Size: 96 T
Price:
Standard Range:15.6-1000 p g/mL
Sample Type: cell cultures, serum, plasma
Sample require: 200 uL
Intra-CV: 4-8%
Inter-CV: 8-10%
Protocol: PDF
  Human Total MMP8 ELISA Kit
Code No.: SK00159-02
Size: 96 T
Price:
Standard Range:62.5-4000 p g/mL
Sample Type: cell cultures, serum, plasma
Sample require: 200 uL
Intra-CV: 4-8%
Inter-CV: 8-10%
Protocol: PDF
  Human MMP1(Total) ELISA Kit
Code No.: SK00164-01
Size: 96 T
Price:
Standard Range:156-20000 p g/mL
Sample Type: cell cultures, serum, plasma
Sample require: 200 uL
Intra-CV: 4-8%
Inter-CV: 6-10
Protocol: PDF
  Human MMP10(Total) ELISA Kit
Code No.: SK00161-01
Size: 96 T
Price:
Standard Range:15.6-1000 p g/mL
Sample Type: cell cultures, serum, plasma
Sample require: 100 uL per well
Intra-CV: 4-8%
Inter-CV: 6-10
Protocol: PDF
Name
Code No.
Size
MMP1 (Total) (Human) ELISA Kit
96 T
MMP3 (Total) (Human) ELISA Kit
96 T
MMP8 (Total) (Human) ELISA Kit
96 T
MMP8 (Total) (Human) ELISA Kit
96 T
MMP9 (Total ) (Human) ELISA Kit
96 T
MMP10 (Total) (Human) ELISA Kit
96 T