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Neuropilin-1(NRP1)
  • Vascular endothelial cell growth factor 165 receptor
  • CD304
  • Receptor for VEGF-145, VEGF, VEGF-B, PlGF, and Sema3A

Neuropilins (Nrp1, Nrp2) are single-pass transmembrane proteins with a large ECD and a short cytoplasmic domain that presents a PDZ binding site (Bagri et al. 2009). Nrps bind to structurally and functionally unrelated ligands, the best studied of which are secreted class III Semaphorins and VEGF family members (Bagri et al. 2009; Ellis, 2006; Gluzman-Poltorak et al. 2000; Neufeld and Kessler 2008; Soker et al. 1998). Initial studies suggested that Semaphorins and VEGF family members could compete for binding to Nrps. However, crystal structures show that VEGF and Semaphorins bind to different parts of the Nrp ECD (Appleton et al. 2007). Sema3A-deficient mice and mutants expressing an Nrp1 variant that cannot bind Sema3A show normal vascular development, arguing that Sema3A is not required for angiogenesis in the mouse (Gu et al. 2003). In contrast, Sema3A, but not VEGF164, is required for axon patterning of limb nerves (Vieira et al. 2007a, b). These data suggest that Nrp1 contributes to both neuronal and vascular patterning by preferentially relaying Sema3A signals in peripheral axons and VEGF164 signals in blood vessels. Furthermore, Semaphorins and VEGF induce Nrp1 endocytosis through different pathways; VEGF binding induces clathrin-mediated endocytosis, whereas Sema3C induces lipid raft-dependent endocytosis (Salikhova et al. 2008). Therefore, each of the two endocytic pathways used by Nrp1 could contribute to its signaling specificity by coupling it to a different set of downstream effectors, depending on which ligand it binds.

 
Adams RH, Eichmann A. Cold Spring Harb Perspect Biol. 2010 May 1;2(5):a001875. Epub 2010 Mar 31.
 
 
 
human soluble Neuropilin 1 ELISA Kit SK00270-01 from Adipo Bioscience Human Soluble Neuropilin-1 (NRP1) ELISA Kit
Code No.: SK00270-01
Size: 96 T
Price: $460.00
Standard range:312-20000 pg/ml
Sensitivity: 30 pg/ml
Sample Type:serum, plasma
Sample require: 100 ul per well
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet: PDF
human soluble neuropilin-1 elisa kit from aviscera bioscience Human Soluble Neuropilin-1 (NRP1) ELISA Kit
Code No.: SK00270-02
Size: 96 T
Price: $460.00
Standard range:312-20000 pg/ml
Sensitivity: 30 pg/ml
Sample Type:serum, plasma
Sample require: 100 ul per well
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet: PDF
human soluble neuropilin 2 elisa kit Human Soluble Neuropilin-2 (NRP2) ELISA Kit
Code No.: SK00520-01
Size: 96 T
Price: $460.00
Standard range:125-8000 pg/ml
Sensitivity: 50 pg/ml
Sample Type:serum, plasma
Sample require: 100 ul per well
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet: PDF
Anti Human Neuropilin-1 IgG
Code No.: A00149-01-100
Size: 100 ug
Price: $260.00 USD
Lot No.: 194A3
Host: rabbit
Antigen: human Neuropilin-1 rec.
Antibody Type: Polyclonal
Purification: Protein A affinity
Applications: E, IHC
Data Sheet: PDF
Human Soluble Neuropilin-1 (NRP1), isoform 2 Recombinant
Code No.: 00270-01-100
Size: 100 ug
Price: $360.00 USD
Protein ID:O14786-2
Gene ID: NM_001024628
MW:87 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF
Human Neuropilin-1, Extracellular Domain Recombinant
Code No.: 00149-01-100
Size: 100 ug
Price: $200.00 USD
Protein ID:O14786
Gene ID: 8829
MW:111.4 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF

 

Name
Code No.
Size
Price ($)
Human Soluble Neuropilin 1 ELISA Kit SK00270-01 96 T 460.00
Human Soluble Neuropilin 1 ELISA Kit SK00270-02 96 T 460.00
Human Soluble Neuropilin 2 ELISA Kit SK00520-01 96 T 460.00
Human Soluble Neuropilin-1 , Isoform 2, Recombinant
00270-01-50
50 ug
260.00
Human Soluble Neuropilin-1 , Isoform 2, Recombinant
100 ug
360.00
Human Soluble Neuropilin-1 , Isoform 2, Recombinant
00270-01-1000
100 ug
inquire
Human Soluble Neuropilin-1 , Biotinylated
00270-01-50B
50 ug
395.00
Human Soluble Neuropilin-1 , Cy3 Conjugated
00270-01-50C3
50 ug
495.00
Human Soluble Neuropilin-1 , Cy5 Conjugated
00270-01-50C5
50 ug
495.00
Human Soluble Neuropilin-1 , FAM Conjugated
00270-01-50FAM
50 ug
460.00
Human Soluble Neuropilin-1 , Rhodamine B Conjugated
00270-01-50RB
50 ug
460.00
Anti Soluble Neuropilin 1 (Human) IgG A00270-02-100 100 ug 260.00
Anti soluble Neuropilin 1 (Human) IgG, Biotinylated A00270-02-50B 50 ug 320.00
Anti Soluble Neuropilin 1 (human) Monoclonal Antibody A00270-06-100 100 ug 360.00
Human Neuropilin-1 , Extracellular Domain
50 ug
300.00
Human Neuropilin-1 , Extracellular Domain
100 ug
460.00
Anti Neuropilin 1 (Human) IgG A00149-01-100 100 ug 260.00