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Pigment Epithelium Derived Factor (PEDF) ELISA Kit
A multifunctional, pleiotropic protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic and neuroprotective properties

Alternative name:

  • Cell proliferation-inducing gene 35 protein
  • Serpin F1
PEDF, a Neurotrophic protein, induces extensive neuronal differentiation in retinoblastoma cells. PEDF is a potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.

Pigment epithelium-derived factor (PEDF) as a therapeutic target in cardiovascular disease
In this review we discuss the role of pigment epithelium-derived factor (PEDF) as a possible new target molecule to therapeutically influence cardiovascular disease. PEDF is a multifunctional, pleiotropic protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic and neuroprotective properties. First identified in retinal pigment epithelium cells, it is expressed in various tissues throughout the body such as the eye, liver and adipose tissue. Recently PEDF has also been characterized in the heart. PEDF has been suggested to have a protective role in atherosclerosis, the main cause of coronary heart disease, myocardial infarction and heart failure due to its anti-inflammatory, antioxidant and antithrombotic effects in the vessel wall and platelets. Additionally PEDF has strong antiangiogenic effects by inducing apoptosis in endothelial cells and by regulating the expression of other angiogenic factors. Therefore blocking of PEDF locally for example in ischemic tissue in the heart might favour angiogenesis, induce neovascularization and lead to increased perfusion of the injured tissue. On the other hand, local overexpression of PEDF restricted to atherosclerotic lesions might block angiogenesis, inflammation and thrombosis at these sites and thus counteract destabilization and rupture of the lesion otherwise caused by inflammatory activation and excessive angiogenesis and inhibit subsequent thrombus formation
Rychli K, Huber K, Wojta J. Expert Opin Ther Targets. 2009 Nov;13(11):1295-302
human PEDF elisa kit sk00283-06 enables to measure human pedf on circulating samples. human pedf elisa kit is available in stock
 Human Pigment Epithelium Derived Factor (PEDF) ELISA Kit
Code No.: SK00283-06
Size: 96 T
Price: $460.00
Standard range:62.5-4000 pg/ml
Sensitivity: 10 pg/ml
Sample Type:serum, plasma
Sample require: 100 ul per well
Intra-CV: 4-6%
Inter-CV: 8-12%
Protocol: PDF
Anti Human PEDF IgG
Code No.: A00283-01-100
Size: 100 ug
Price: $260.00 USD
Host: Rabbit
Antigen: human PEDF Rec.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC, WB
Working Dilution: 2-4 ug/ml)
Data Sheet: PDF
anti PEDF antibody enables to detect PEDF on human serum samples aviscera bioscience
 Anti Human PEDF IgG
Code No.: A00283-01-100
Size: 100 ug
Price: $260.00 USD
Host: Rabbit
Antigen: human PEDF Rec.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC, WB
Working Dilution: 2-4 ug/ml)
Data Sheet: PDF

human PEDF recombinant

 Human PEDF Recombinant
Code No.: 00283-01-100
Size: 100 ug
Price: $360.00 USD
Protein ID:P36995
Gene ID: 5176
MW: 50.23 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF

 

 

Name
Code No.
Size
Price ($)
Pigment Epithelium Derived Factor (PEDF) (Human) ELISA Kit SK00283-06 96 T 460.00
Human PEDF Recombinant 00283-01-50 50 ug 230.00
Human PEDF  Recombinant
100 ug
360.00
Anti PEDF (Human) IgG
100 ug
260.00