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Soluble IL-1 Receptor 4/ST2 (sIL-1R4/ST2/IL1RL1) ELISA Kit Antibody, Recombinant
A Biomarker for Cardiovascular Diseases

Alternative name:

  • ST2
  • IL-1R4
ST2, a member of the interleukin-1 receptor family, is a novel biomarker of mechanical stress measurable in serum that has been shown in animal and in vitro models to be physiologically linked to cardiac hypertrophy, fibrosis, and ventricular dysfunction. In patients with acute myocardial infarction and heart failure (HF), an elevated serum level of the soluble isoform of ST2 is associated with an increased risk of mortality or future HF, independent of natriuretic peptides, and correlates with markers of ventricular structure and function. In acute HF, elevated soluble ST2 levels strongly associate with the presence and severity of the disease and forecast short- and long-term mortality independent of other traditional clinical, biochemical, and echocardiographic markers of risk. This review discusses the biology and physiology of ST2, as well as its implications on the pathogenesis and prognosis of patients with acute coronary syndromes or acute and chronic HF syndromes.
Shah RV, Januzzi JL Jr. Curr Heart Fail Rep. 2010 Mar;7(1):9-14.
Daniels LB, et al. Am Heart J. 2010 Oct;160(4):721-8.
Interleukin-33 is a newly recognized cytokine of the IL-1 family. Unlike its other members IL-1α, IL-1β and IL-18, interleukin-33 induces predominantly Th2-skewed immune responses. In this context, the effects of IL-33 are mostly anti-inflammatory. However, depending on the actual cytokine and cellular milieu, IL-33 can promote both Th1 and Th2 immune reactions. Most importantly for cardiology and cardiac surgery, IL-33 has emerged to represent the as yet unknown ligand of the orphan receptor ST2. Before the advent of IL-33, the ST2 receptor, currently recognized as the soluble one of its two isoforms, was considered to be an unfavorable prognostic marker in myocardial infarction, congestive heart failure and trauma/sepsis shock patients. Now we know that IL-33, when bound to the cellular membrane-anchored ST2L isoform of the receptor, can have certain beneficial effects on the aforementioned conditions. Various forms of IL-33 interaction with the respective isoforms of its cognate receptor are discussed here. The focus is on physiological and prognostic values in cardiac patients.
Kunes P, et al. Thorac Cardiovasc Surg. 2010 Dec;58(8):443-9. Epub 2010 Nov 26.
Human Soluble ST2/IL-1R4/IL1RL1 ELISA Kit
Code No.: SK00120-06
Size: 96T
Price: $390.00 USD
Standard Range:31-800 pg/mL
Sensitivity:15 pg/mL
Sample Type: serum, EDTA Plasma
Sample volume: 100 uL
Dilution factor:Optimal dilutions should be determined by each laboratory for each application
IntraCV: 4-6%
InterCV: 8-12%
Protocol: PDF
mouse st2 elisa kit
Mouse Soluble ST2/IL-1R4ELISA Kit
Code No.: SK00120-07
Size: 96T
Price: $360.00 USD
Standard Range: 78 -5000 pg/mL
Sensitivity:26 pg/mL
Sample Type: serum, EDTA Plasma
Sample volume: 100 uL
Dilution factor: 5
IntraCV: 4-6%
InterCV: 8-12%
Protocol: PDF
Mouse Soluble ST2/IL-1R4ELISA Kit
Code No.: SK00120-03
Size: 96T
Price: $360.00 USD
Standard Range: 0.312-20 ng/mL
Sensitivity:0.15 ng/mL
Sample Type: serum, EDTA Plasma
Sample volume: 100 uL
Dilution factor: 5
IntraCV: 4-6%
InterCV: 8-12%
Protocol: PDF
 
 

Ligand for IL1RL1/ST2: IL-33

 

Name
Code No.
Size
Price ($)
Soluble ST2/IL-1RL1 (Human) ELISA Kit
96 T
390.00
Soluble ST2/IL1RL1 (Human) ELISA Kit
SK00120-06B
2 x 96 T
720.00
Mouse Soluble ST2/IL-1R4 ELISA Kit
96 T
360.00
Human Soluble IL-1R1 ELISA Kit
96 T
360.00
Human Soluble IL-1R2 ELISA Kit
96 T
360.00
       
Human ST2/IL-1RL1 Rec. (human cells derived)
10 ug
90.00
Human ST2/IL-1RL1 Rec. (human cells derived)
50 ug
340.00
Human ST2/IL1RL1. (human cells derived)
00120-09-100
100 ug
490.00
Human ST2/IL-1RL1 Rec. Biotinylated (human cells derived)
20 ug
490.00
Human ST2/IL-1RL1 Fc Fusion (human cells derived)
00120-10-10
10 ug
90.00
Human ST2/IL-1RL1 Fc Fusion (human cells derived)
00120-10-50
50 ug
340.00
Human ST2/IL-1RL1 Fc Fusion (human cells derived)
00120-10-100
50 ug
490.00
Human ST2/IL-1RL1 Fc Fusion, Biotinylated (human cells derived)
00120-10-20
20 ug
490.00
Anti ST2/ IL-1RL1 (Human) Monoclonal Antibody (Capture)
100 ug
320.00
Anti ST2/ IL-1RL1 (Human) MAB (Capture)
A00120-10-500
500 ug
620.00
Anti ST2/ IL-1RL1 (Human) MAB Biotinylated (Detection)
A00120-12-50B
50 ug
329.00
Anti ST2/ IL-1RL1 (Human) MAB Biotinylated (Detection)
A00120-12-100B
100 ug
619.00
Anti ST2/ IL-1RL1 (Human) MAB Biotinylated (Detection)
A00120-12-200B
200 ug
1090.00
Anti ST2/ IL-1RL1 (Human) Monoclonal Antibody
100 ug
320.00
Anti ST2/ IL-1RL1 (Human) Monoclonal Antibody
500 ug
619.00
Anti ST2/ IL-1RL1 (Human) Monoclonal Antibody
100 ug
320.00
Anti ST2/ IL-1RL1 (Human) Monoclonal Antibody
500 ug
619.00