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V-set and transmembrane domain containing 2 like (VSTM2L)is a antagonist of humanin

Alternative name:

  • C20orf102

VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin

Humanin (HN) is a 24-residue peptide displaying a protective activity in vitro against a range of cytotoxic and neurotoxic insults, as well as mediating in vivo amelioration of Alzheimer disease (AD)-related memory impairment in experimental models. Published evidence suggests that the mechanisms through which HN exerts its cyto- and neuroprotective activity may include its secretion and binding to membrane-associated receptors. Here, we describe the identification of a new modulator of HN neuroprotective activity, V-set and transmembrane domain containing 2 like (VSTM2L), previously known as C20orf102. VSTM2L interacts with HN in both yeast and mammalian cells, is secreted in cultured cells, is present in serum, and is selectively expressed in the central nervous system. VSTM2L colocalizes with HN in distinct brain areas as well as in primary cultured neurons, where it plays a role in the modulation of neuronal viability. When tested in HN neuroprotection bioassays, VSTM2L acts as a strong antagonist of HN neuroprotective activity. In summary, VSTM2L is the first example of a secreted antagonist of HN and may play a role in the modulation of HN biological functions—Rossini, L., Hashimoto, Y., Suzuki, H., Kurita, M., Gianfriddo, M., Scali, C., Roncarati, R., Franceschini, D., Pollio, G., Trabalzini, L., Terstappen, G. C., Matsuoka, M., Caricasole, A. VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.
Lara Rossini, et al. Published online before print March 10, 2011, doi: 10.1096/fj.10-163535 fj.10-163535
 
 
VSTM2L recombinant is from adipo bioscience
anti human VSTM2L antibody from aviscera bioscience Anti Human VSTM2L   IgG
Code No.: A00820-01-100
Size: 100 ug
Price: $260.00 USD
Host: Rabbit
Antigen: human VSTM2L Rec.
Ab Type:  IgG1
Purification: Protein A
Applications: E, IHC
Data Sheet: PDF
anti human VSTM2L antibody from aviscera bioscience Anti Human VSTM2L   IgG
Code No.: A00820-03-100
Size: 100 ug
Price: $260.00 USD
Host: Rabbit
Antigen: human VSTM2L (25-166) Rec.
Ab Type:  IgG
Purification: Protein A
Applications: E, IHC
Data Sheet: PDF

Human VSTM2L  Recombinant
Code No.: 00820-01-100
Size: 100 ug
Price: $460.00 USD
Protein ID:Q96N03
Gene ID: 128434
MW: 23.83 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF
Human VSTM2L(25-132)  Recombinant
Code No.: 00820-02-100
Size: 100 ug
Price: $360.00 USD
Protein ID:Q96N03
Gene ID: 128434
MW: 15.93 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF
   
human vstm2l recombinant from adipo bioscience Human VSTM2L(25-166)  Recombinant
Code No.: 00820-03-100
Size: 100 ug
Price: $360.00 USD
Protein ID:Q96N03
Gene ID: 128434
MW: 19.83 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF

 

Name/td>
Code No.
Size
Price ($)
VSTM2L (Human), recombinant
100 ug
460.00
VSTM2L (Human), Cy3 conjugated
00820-01-50C3
50 ug
590.00
VSTM2L (Human), FAM conjugated
00820-01-50FAM
50 ug
560.00
VSTM2L (Human), biotinylated
00820-01-50B
50 ug
540.00
Anti VSTM2L (Human) IgG
100 ug
260.00
Anti VSTM2L (Human)IgG
A00820-06-100
100 ug
360.00
VSTM2L (25-132) (Human) Rec.
100 ug
360.00
VSTM2L (25-166) (Human) Rec. 00820-03-100 100 ug 360.00
Anti VSTM2L (25-166) (Human) IgG A00820-03-100 100 ug 260.00
Anti VSTM2L (25-166) (Human) IgG Biotinylated A00820-03-50B 100 ug 260.00