AVISCERA BIOSCIENCE
 
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 chemerin (human) ELISA Kit

Elevated plasma levels of chemerin in newly diagnosed type 2 diabetes mellitus with hypertension

Swiss-Prot entry Q99541; ADRP is the major lipid droplet protein. May be involved in development and maintenance of adipose tissue. Human ADRP, 437 amino acids, MW 48074 Da

Chemerin is a recently discovered metabolic regulator hormone. The pathophysiologic role of this hormone in humans remains unknown. In this study, we have compared plasma chemerin levels in patients with type 2 diabetes mellitus with or without hypertension and in control subjects. We also assessed the association of plasma chemerin with body composition and metabolic parameters in these subjects. Plasma chemerin levels were found to be markedly increased in patients with type 2 diabetes mellitus with hypertension as compared with patients with type 2 diabetes mellitus and normal controls (P < 0.01). Multiple regression analysis showed that waist circumference, diastolic blood pressure, 2-hour plasma insulin after glucose overload, and HbA1c were independently related factors influencing plasma chemerin levels. The present work indicates the potential link of chemerin with the pathogenesis of insulin resistance, obesity, and metabolic syndrome. 

Yang M, Yang G, Dong J, Liu Y, Zong H, Liu H, Boden G, Li L. J Investig Med. 2010 Oct;58(7):883-6. 

More references

1: Parlee SD, et al. Serum chemerin levels vary with time of day and are modified by obesity and tumor necrosis
factor-{alpha}. Endocrinology. 2010 Jun;151(6):2590-602. Epub 2010 Apr 2.
2: Bozaoglu K, et al. Chemerin, a novel adipokine in the regulation of angiogenesis. J Clin Endocrinol Metab. 2010 May;95(5):2476-85. Epub 2010 Mar 17.
3: Ernst MC, Issa M, Goralski KB, Sinal CJ. Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes. Endocrinology. 2010 May;151(5):1998-2007. Epub 2010 Mar 12
4: Pfau D, et al . Circulating Levels of the Adipokine Chemerin in Gestational Diabetes Mellitus. Horm Res Paediatr. 2010 Apr 29. [Epub ahead of  print]
5: Ress C, et al. Effect of bariatric surgery on circulating chemerin levels. Eur J Clin Invest. 2010 Mar;40(3):277-80. Epub 2010 Jan 25.
6: Spiroglou SG, et al. Adipokines in periaortic and epicardial adipose tissue: differential expression and relation to atherosclerosis. J Atheroscler Thromb. 2010 Feb 26;17(2):115-30. Epub 2010 Feb 10.

   
Human Chemerin ELISA
Code No.: SK00171-02
Size: 96 T
Price: $360.00 USD
Standard Range:0.78-50 ng/ml
Sensitivity:  50 pg/ml
Sample Type: serum, EDTA plasma
Dilution factor: 100 Sample requres: 10 uL
IntraCV: 6-8%
InterCV: 10-12%
Protocol: PDF
Human Chemerin ELISA
Code No.: SK00171-01
Size: 96 T
Price: $420.00 USD
Standard Range:31.2-2000 pg/ml
Sensitivity:  10 pg/ml
Sample Type: serum, EDTA plasma
Dilution factor: 100 Sample requres: 10 uL
IntraCV: 6-8%
InterCV: 10-12%
Protocol: PDF
 

 

 
 
Name
Code No.
Size
Price
Human Chemerin ELISA
96 T
360.00
Human Chemerin ELISA
96 T
420.00
Human chemerin recombinant
100 ug
360.00
Anti Human chemerin ,IgG
100 ug
220.00
Anti Human chemerin ,Monoclonal Antibody
100 ug
260.00
Anti Human chemerin ,Monoclonal Antibody
100 ug
260.00
Anti Human chemerin ,Monoclonal Antibody
100 ug
260.00
Anti Chemerin (Human) IgG Biotinylated (Detection)
50 ug
290.00
Anti Chemerin (Human) IgG Biotinylated (Detection)
100 ug
490.00