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Alternative name:

  • ADAM Metallopeptidase Domain 15
  • A Disintegrin And Metalloproteinase Domain 15 (Metargidin)
  • Metalloprotease RGD Disintegrin Protein

Sun C., et al. Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2444-51

A disintegrin and metalloprotease -8 and -15 and susceptibility for ascending aortic dissection

BACKGROUND. Dilatation of the ascending aorta (AA) is affected by extra-cellular matrix modifications and inflammation. A disintegrin and metalloproteases (ADAMs) may reveal differences between AA and ascending aortic dissection (AD). We characterized the inflammatory histology of AD and AA and examined the role of ADAM8 and -15 in these diseases. MATERIAL AND METHODS. Aortic wall histology and immunohistochemistry for leukocytes, T- and B-lymphocytes, plasma cells, macrophages, endothelial cells, smooth muscle cells, cell proliferation, elastase and Van-Gieson-staining were performed to 40 consecutive patients that underwent surgery for AA or AD. The expressions of ADAM8 and -15 mRNA and proteins were evaluated using QRT-PCR and immunohistochemistry. RESULTS. Thirty-four patients were enrolled, of which 29 had AA and five had AD of the ascending aorta. B-cells throughout the aortic wall and intimal plasma cells were more numerous during AD as compared with AA (p < 0.05). The gene expressions for ADAM8 and -15 were notably lower in AA as compared with AD. The median for down-regulation of ADAM8 and -15 in AA was -2.7 and -1.8, respectively. ADAM8 and -15 were mainly found in the media layer in patients with AD. Two of the patients with AA and increased ADAMs developed AD of the remaining aorta. CONCLUSIONS. The involvement of ADAM8 and -15 together with inflammation consisting of B-cells may indicate active remodelling of the aortic wall leading to AD.
Levula M et al. Scand J Clin Lab Invest. 2011 Oct;71(6):515-22.

human ADAM15 ELISA kit

Human Soluble ADAM15 ELISA
Code No.: SK00754-01
Size: 96 T
Price: $420.00 USD
Standard Range:47-3000 pg/ml
Sensitivity: 10 pg/ml
Sample Type: serum, plasma
Sample Volume: 100 uL of diluted samples
Dilution Factor:
Intra CV: 4-6%
Inter CV: 8-10%
Protocol: PDF


Code No.
Price ($)
Human Soluble ADAM15 ELISA Kit
96 T