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Soluble CD137 Ligand/4-1BB Ligand/TNFSF9

Alternative name:

  • 4-1BB ligand
  • CD137L
  • TNFSF9

CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells.
Natural killer (NK) cells play an important role in the immunosurveillance of leukemia. Their reactivity is governed by a balance of activating and inhibitory receptors including various members of the tumor necrosis factor receptor (TNFR) family. Here we report that human NK cells acquire expression of the TNFR family member CD137 upon activation, and NK cells of acute myeloid leukemia (AML) patients display an activated phenotype with substantial CD137 expression. CD137 ligand (CD137L) was detectable on leukemic cells in 35% of 65 investigated AML patients, but not on healthy CD34(+) cells, and expression was associated with monocytic differentiation. Bidirectional signaling following CD137-CD137L interaction induced the release of the immunomodulatory cytokines interleukin-10 and TNF by AML cells and directly diminished granule mobilization, cytotoxicity, and interferon-gamma production of human NK cells, which was restored by blocking CD137. Cocultures of NK cells with CD137L transfectants confirmed that human CD137 inhibits NK-cell reactivity, while activating signals were transduced by its counterpart on NK cells in mice. Our data underline the necessity to study the function of seemingly analog immunoregulatory molecules in mice compared with men and demonstrate that CD137-CD137L interaction enables immune evasion of AML cells by impairing NK-cell tumor surveillance in humans.
Baessler T, , et al Blood. 2010 Apr 15;115(15):3058-69. Epub 2009 Dec 14.

Human Soluble 4-1BB Ligand/CD137 Ligand Recombinant
Code No.: 00456-01-100
Size: 100 ug
Price: $360.00 USD
Protein ID:P41273
Gene ID: 8744
MW:25 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF
  Anti Human Soluble 4-1BB Ligand/CD137 Ligand IgG
Code No.: A00456-01-100
Size: 100 ug
Price: $260.00 USD
Host: Rabbit
Antigen: ECD of human CD137L rec.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC
Working Dilution: IHC 1: 250 (4 ug/ml)
Data Sheet: PDF
  Anti Human Soluble 4-1BB Ligand/CD137 Ligand IgG Biotinylated 
Code No.: A00456-01-30B
Size: 50 ug
Price: $290.00 USD
Host: Rabbit
Antigen: ECD of human CD137L rec.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC
Working Dilution: IHC 1: 250 (4 ug/ml)
Data Sheet: PDF
Name
Code No.
Size
Price ($)
Soluble 4-1BB Ligand/CD137 Ligand (Human) ,Rec.
00456-01-50
50 ug
220.00
Soluble 4-1BB Ligand/CD137 Ligand (Human) ,Rec.
100 ug
360.00
Soluble 4-1BB Ligand/CD137 Ligand (Human) ,Rec.
00178-01-1000
1000 ug
3200.00
Anti Soluble CD137 Ligand (Human) IgG A00456-01-100 100 ug 260.00
Anti Soluble CD137 Ligand (Human) IgG Biotinylated A00456-01-50B 50 ug 290.00