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Soluble CD48 (Human) ELISA Kit
A biomarker for cancer and CVD
Defects in natural killer (NK) cell functions are necessary for tumor immune escape, but their underlying regulatory mechanisms in human cancers remain largely unknown. Here we show, in detailed studies of NK cells in 294 untreated patients with hepatocellular carcinoma (HCC), that accumulation of functional NK cells in HCC tissues could predict improved survival of patients. However, in patients with advanced-stage HCC, NK cells were significantly decreased in number with impaired tumor necrosis factor alpha (TNF-α) and interferon-gamma (IFN-γ) production. High infiltration of peritumoral stroma monocytes/macrophages was positively correlated with impaired functional activities of NK cells in intratumoral areas. Further kinetic experiments revealed that soon after exposure to tumor-derived monocytes, NK cells underwent a rapid, transient activation, but then they became exhausted, and eventually died. The monocytes from HCC tissues, but not from nontumoral liver, strongly express CD48 proteins; and such monocyte-induced NK cell dysfunction was markedly attenuated by blocking CD48 receptor 2B4 on NK cells, but not by blockade of NKG2D and NKp30.
Wu Y et al. Hepatology. 2013 Mar;57(3):1107-16 
human soluble CD48 elisa kit from aviscera bioscience Human Soluble CD48 ELISA Kit
Code No.: SK00494-01
Size: 96 T
Price: $420.00
Standard range:15.6-500 pg/ml
Sensitivity: 7.5 pg/ml
Sample Type:serum, plasma
Dilution Factor: 10-20
Sample require: 100 ul per well
Inter-CV: 8-12%
Data Sheet: PDF


Price ($)

Soluble CD48 (Human) ELISA Kit

96 T


Soluble CD48 (Human) Standard. (293 cells derived)
500 pg