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Soluble CD69ELISA
The CD69 was expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. CD69 involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.


human soluble CD69
human soluble Cd69 sequence

CD69 is independently prognostic in chronic lymphocytic leukemia: a comprehensive clinical and biological profiling study

BACKGROUND: CD69 is expressed in several hemopoietic cells and is an early activation marker in chronic lymphocytic leukemia. Chronic lymphocytic leukemia is a clinically heterogeneous disease which needs novel prognostic parameters which can be easily and efficiently managed.
DESIGN AND METHODS: We investigated CD69 by flow cytometry in a series of 417 patients affected by chronic lymphocytic leukemia and compared this to other biological and clinical prognosticators.
RESULTS: CD69 was associated with Rai stages (P=0.00002), β(2)-microglobulin (P=0.0005) and soluble CD23 (P<0.0001). CD69 and ZAP-70 (P=0.018) or CD38 (P=0.00015) or immunoglobulin variable heavy chain gene mutations (P=0.0005) were also significantly correlated. Clinically, CD69 positive chronic lymphocytic leukemias received chemotherapy more frequently (74%; P<0.0001), and presented a shorter duration of response after fludarabine plus rituximab (P=0.010) as well as shorter progression free survival and overall survival (P<0.0001). CD69 demonstrated true additive prognostic properties, since the CD69(+) plus ZAP-70(+) or CD38(+) or immunoglobulin variable heavy chain gene unmutated patients had the worst progression free survival and overall survival (P<0.0001). Interestingly, low CD69 expression was necessary to correctly prognosticate the longer progression free survival of patients with a low tumor burden of β(2)-microglobulin (P=0.002), of soluble CD23 (P=0.020), or of Rai stages 0-I (P=0.005). CD69 was confirmed to be an independent prognostic factor in multivariate analysis of progression free survival (P=0.017) and overall survival (P=0.039).
CONCLUSIONS:Our data indicate that CD69 is significantly correlated with poor clinical and biological prognostic factors and is confirmed to be an independent disease prognosticator. This supports its introduction in a routine laboratory assessment and, possibly, in a prognostic scoring system for chronic lymphocytic leukemia, after an adequate standardization process.
Del Poeta G et al. Haematologica. 2012 Feb;97(2):279-87.
  Human Soluble CD69 ELISA Kit
Code No.: SK00498-01
Size: 96 T
Price: $420.00 USD
Standard range15.6-1000 pg/ml
Sensitivity: 10 pg/ml
Sample Type: serum, plasma
sample require:100 uL per well
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet: PDF


Human Soluble CD69 Recombinant
Code No.: 00498-01-10
Size: 10 ug
Price: $150.00 USD
Protein ID:NP_0017702
Gene ID: NM_0017781
MW:40 KD (homodimer)
Tag: His Tag on C-Terminus
Expressed: 293 cells derived
Purity: 90%
Data Sheet: PDF
Anti Human Soluble CD69 IgG
Code No.: A00498-01-50
Size: 50 ug
Price: $260.00 USD
Host: Rabbit
Antigen: human CD69 ECD
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, WB
Working Dilution: 1-2 ug/ml)
Data Sheet: PDF



Code No.
Price ($)
Soluble CD69 (Human) ELISA Kit SK00498-01 96 T 420.00
Soluble CD69(Human) standard
10 ug
Anti Soluble CD320 (Human) Monoclonal Antibody
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Anti Soluble CD320 (Human) IgG
100 ug