aviscera bioscience  
AVISCERA BIOSCIENCE  
line decor
  HOME  ::  
line decor
   
 
CXCL1/Growth-regulated alpha protein (GRO-ALPHA)

Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression

The chemokine CXC ligand-1 (CXCL-1) is a small cytokine that elicits effects by signalling through the chemokine receptor CXCR2. CXCL-1 has neutrophil chemoattractant activity, is involved in the processes of angiogenesis, inflammation and wound healing, and may possess neuroprotective effects. The aim of this study was to unravel the mechanisms whereby CXCL-1 is regulated by exercise inmice. After a single bout of exercise, CXCL-1 protein increased in serum(2.4-fold), and CXCL-1 mRNA in muscle (6.5-fold) and liver (41-fold). These increases in CXCL-1 were preceded by increases in serum interleukin-6 (IL-6) and muscle IL-6 mRNA. In contrast, exercise-induced regulation of liver CXCL-1 mRNA expression was completely blunted in IL-6 knockout mice. Based on these findings, we examined the possible existence of a muscle-to-liver axis by overexpressing IL-6 in muscles. This resulted in increases in serum CXCL-1 (5-fold) and liver CXCL-1 mRNA expression (24-fold) compared with control. Because IL-6 expression and release are known to be augmented during exercise in glycogen-depleted animals, CXCL-1 and IL-6 expression were examined after exercise in overnight-fasted mice.We found that fasting significantly augmented serum CXCL-1, and CXCL-1 expression in liver and muscle. Taken together, these data indicate that liver is the main source of serum CXCL-1 during exercise in mice, and that the CXCL-1 expression in the liver is regulated by muscle-derived IL-6.
Pedersen L et al. J Physiol. 2011 Mar 15;589(Pt 6):1409-20. Epub 2011 Jan 4.
  HumanCXCL1/GRP-alpha ELISA
Code No.: SK00427-01
Size: 96 T
Price: $360.00 USD
Standard Range:15.6-1000 pg/ml
Sensitivity:10 pg/ml
Sample Type: serum, EDTA plasma
Sample requres: 220 ul, 100 ul per well
IntraCV:6-8%
InterCV: 10-12%
Protocol: PDF
  Human GRO-alpha/CXCL1 Recombinant
Code No.: 00427-01-100
Size: 100 ug
Price: $360.00 USD
Protein ID:P09341
Gene ID: 2919
MW:10 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 90%
Data Sheet: PDF
Anti Human GRO-alpha/CXCL1 IgG
Code No.: A00427-01-100
Size: 100 ug
Price: $220.00 USD
Host: Rabbit
Antigen: human GRO-alpha.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC, WB
Working Dilution: 2-4 ug/ml)
Data Sheet: PDF
Anti Human GRO-alpha/CXCL1 IgG
Code No.: A00427-01-100
Size: 100 ug
Price: $220.00 USD
Host: Rabbit
Antigen: human GRO-alpha.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC, WB
Working Dilution: 2-4 ug/ml)
Data Sheet: PDF
Name
Code No.
Size
Price ($)
Human CXCL1/GRP-alpha ELISA Kit
96 T
360.00
Human GRO-alpha Rec
100 ug
360.00
Anti Human GRO-alpha/CXCL1 IgG
100 ug
220.00

More GRO-alpha related products:

  • IL-8