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GDF-11/Bone Morphogenetic Protein 11 (BMP11) Recombinant, Antibody, ELISA Kit |
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Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting that young blood contains humoral "rejuvenating" factors that can restore regenerative function. Here, we demonstrate that the circulating protein growth differentiation factor 11 (GDF11) is a rejuvenating factor for skeletal muscle. Supplementation of systemic GDF11 levels, which normally decline with age, by heterochronic parabiosis or systemic delivery of recombinant protein, reversed functional impairments and restored genomic integrity in aged muscle stem cells (satellite cells). Increased GDF11 levels in aged mice also improved muscle structural and functional features and increased strength and endurance exercise capacity. These data indicate that GDF11 systemically regulates muscle aging and may be therapeutically useful for reversing age-related skeletal muscle and stem cell dysfunction. |
Sinha M, et al, Science. 2014 May 9;344(6184):649-52 |
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy |
The most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac hypertrophy in aging, we tested the influence of circulating factors using heterochronic parabiosis, a surgical technique in which joining of animals of different ages leads to a shared circulation. After 4 weeks of exposure to the circulation of young mice, cardiac hypertrophy in old mice dramatically regressed, accompanied by reduced cardiomyocyte size and molecular remodeling. Reversal of age-related hypertrophy was not attributable to hemodynamic or behavioral effects of parabiosis, implicating a blood-borne factor. Using modified aptamer-based proteomics, we identified the TGF-β superfamily member GDF11 as a circulating factor in young mice that declines with age. Treatment of old mice to restore GDF11 to youthful levels recapitulated the effects of parabiosis and reversed age-related hypertrophy, revealing a therapeutic opportunity for cardiac aging. |
Loffredo FS et al. Cell. 2013 May 9;153(4):828-39 |
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Code No.: 00337-06-100
Size: 100 ug
Price: $420.00 USD
Protein ID:NP_034402
Gene ID: NM_010272
MW: 15 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF |
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Code No.: A00337-06-100
Size: 100 ug
Price: $220.00 USD
Host:Rabbit
Immunogen: h/m/r GDF-11, mature
Antibody Type: Polyclonal IgG
Purification: Protein A
Application: E, IHC, WB
Data Sheet: PDF |
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Code No.: A00337-06-100
Size: 100 ug
Price: $220.00 USD
Host:Rabbit
Immunogen: h/m/r GDF-11, mature
Antibody Type: Polyclonal IgG
Purification: Protein A
Application: E, IHC, WB
Data Sheet: PDF |
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Code No. |
Size |
Price ($) |
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GDF-11/BMP11 (Human Mouse Rat), Rec. |
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50 ug |
260.00 |
GDF-11/BMP11 (Human Mouse Rat), Rec. |
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100 ug |
420.00 |
GDF-11/BMP11 (Human Mouse Rat), Rec. |
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1mg |
3800.00 |
GDF-11/BMP11 (Human Mouse Rat), Biotinylated |
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50 ug |
260.00 |
Anti GDF-11/BMP11 (Human Mouse Rat) IgG |
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100 ug |
290.00 |
Anti GDF-11/BMP11 (Human Mouse Rat) IgG Biotinylated |
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50 ug |
350.00 |
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