GRANULINs (GRN) ELISA, Recombinat, Antibody A Biomarker for Alzheimer's Disease & Tumors
Proepithelin Granulin-epithelin Acrogranin proepithelin
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. .
	Human Grnulin / Progranulin (GRN)ELISA Code No.: SK00313-02 Size: 96 T Price: $360.00 USD Standard Range: 15.6-1000 pg/ml Sensitivity:5 pg/ml Sample Type: serum, EDTA plasma, CSF Sample requres: 100 ul per well IntraCV: 4-6% InterCV: 10-12% Protocol: PDF
	Human Acrogranin (GRN)ELISA Code No.: SK00313-06 Size: 96 T Price: $360.00 USD Standard Range: 0.32-200 ng/ml Dynamic Range: 2- 200 ng/ml Sensitivity:1.6 ng/ml Sample Type: serum, EDTA plasma, CSF Sample requres: 25 ul, 50 ul of 5-fold diluted samples per well IntraCV: 6-8% InterCV: 10-12% Protocol: PDF
	Rat/Mouse Acrogranin (GRN) ELISA Code No.: SK00313-03 Size: 96 T Price: $420.00 USD Standard Range: 0.32-200 ng/ml Dynamic Range: 2- 200 ng/ml Sensitivity:1.6 ng/ml Sample Type: serum, EDTA plasma, CSF Sample requres: 25 ul, 50 ul of 5-fold diluted samples per well IntraCV: 6-8% InterCV: 10-12% Protocol: PDF
	Human Acrogranin (GRN)Recombinant Code No.: 00313-01-100 Size: 100 ug Price: $360.00 USD Protein ID:P28799 Gene ID: 2896 MW: 63 KD Tag: His Tag on N-Terminus Expressed: E. Coli Purity: 90% Data Sheet: PDF
	Anti Human Acrogranin (GRN)IgG Code No.: A00313-01-100 Size: 100 ug Price: $260.00 USD Host: Rabbit Antigen: human Acrogranin (GRN) Rec. Ab Type: Polyclonal IgG Purification: Protein A Applications: E, IHC, Working Dilution: IHC 1: 500 (2 ug/ml) Data Sheet: PDF
	Anti Human Acrogranin (GRN)IgG Code No.: A00313-01-100 Size: 100 ug Price: $260.00 USD Host: Rabbit Antigen: human Acrogranin (PGRN) Rec. Ab Type: Polyclonal IgG Purification: Protein A Applications: E, IHC, Working Dilution: IHC 1: 500 (2 ug/ml) Data Sheet: PDF
	Rat Granulin (GRN)(18-334)Recombinant Code No.: 00313-02-100 Size: 100 ug Price: $360.00 USD Protein ID:Q61N42 Gene ID: 29143 MW: 37.6 KD Tag: His Tag on N-Terminus Expressed: E. Coli Purity: 90% Data Sheet: PDF
	Rat Granulin  (GRN) (361-511)Recombinant Code No.: 00313-06-100 Size: 100 ug Price: $360.00 USD Protein ID:Q61N42 Gene ID: 29143 MW: 19.9 KD Tag: His Tag on N-Terminus Expressed: E. Coli Purity: 90% Data Sheet: PDF

REFERENCES:

• Han JJ, et al. Progranulin is a potential prognostic biomarker in advanced epithelial ovarian cancers. Gynecol Oncol. 2010  Oct 13. [Epub ahead of print]
• Piscopo P, et al. Hypoxia induces up-regulation of progranulin in neuroblastoma cell lines. Neurochem Int. 2010 Oct 7. [Epub ahead of print]
• Schofield EC, et al. Low Serum Progranulin Predicts the Presence of Mutations: A Prospective Study. J Alzheimers Dis. 2010 Sep 21. [Epub ahead of print]
• Sleegers K, et al. Role of progranulin as a biomarker for Alzheimer's disease. Biomark Med. 2010 Feb;4(1):37-50. Review.
• De Riz M, et al. Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes. Neurosci Lett. 2010 Jan 22;469(2):234-6. Epub 2009 Dec 4.