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Glypican 3 ELISA Kit
A Biomarker for Hepatocellular Carcinoma
  • GPC-3

Positive glypican-3 expression in early hepatocellular carcinoma predicts recurrence after hepatectomy

BACKGROUND: Glypican-3 (GPC3) is a new prognostic factor after curative hepatectomy in patients with hepatocellular carcinoma (HCC), and the expression of GPC3 is known to be associated with postoperative metastasis. However, the role of GPC3 in patients with early HCC remains unknown
METHODS: We retrospectively studied 55 patients with early HCC (total 99 nodules) who underwent initial hepatectomy between 1995 and 2010. Clinicopathological features and surgical outcomes were compared in relation to GPC3 expression.
RESULTS: The GPC3-positive expression was seen in 28 of 55 patients (50.9 %) with early HCC (44 of 99 nodules). The GPC3-positive expression was significantly associated with hepatitis C virus (HCV) infection (P = 0.0019) and with multiple early HCCs (P < 0.0001). The 5-year disease-free survival rate was significantly lower in patients with GPC3-positive early HCC (27 %) than in patients with GPC3-negative early HCC (62 %, P = 0.0036). The GPC3 expression was a significant independent prognostic factor for disease-free survival. However, it showed no significant difference in overall survival.
CONCLUSIONS: The GPC3 expression is capable to be a new prognostic factor for disease-free survival in patients with early HCC.

Chen IP et al. J Gastroenterol. 2013 Mar 27.
Human Glypican-3 ELISA Kit
Code No.: SK00247-01
Size: 96 T
Price: $340.00
Standard range:125-8000 pg/ml
Sensitivity: 50 pg/ml
Sample Type:serum, plasma
Sample require: 100 ul per well
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet: PDF
Code No.
Price ($)
Glypican-3 (Human) ELISA Kit
96 T