IL-1F9 (Human ) ELISA Kit,Recombinant, Antibody |
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| Functions: Agonist via the IL-1Rrp2 receptor. Increases IL-6, IL-8 production in epithelial cells | |
Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungs |
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| Interleukin-1 (IL-1) is a proinflammatory cytokine that signals through the Type I IL-1 receptor (IL-1RI). Novel IL-1-like cytokines were recently identified. Their functions in lung disease remain unclear. Interleukin-1 family member-9 (IL-1F9) is one such IL-1-like cytokine, expressed in the lungs of humans and mice. IL-1F9 signals through IL-1 receptor-related protein 2 (IL-1Rrp2/IL-1RL2), which is distinct from IL-1RI. We sought to determine if IL-1F9 acts as a proinflammatory cytokine in lung disease. IL-1F9 protein was increased in lung homogenates of house dust mite-challenged A/J mice compared with controls, and expression was seen in airway epithelial cells. The intratracheal administration of recombinant mouse IL-1F9 increased airway hyperresponsiveness and induced neutrophil influx and mucus production, but not eosinophilic infiltration in the lungs of mice. In addition, IL-1α protein levels in bronchoalveolar lavage fluid, chemokines, and chemokine-receptor mRNA expression in the lungs were increased after the instillation of intratracheal IL-1F9. Consistent with these changes, NF-κB transcription factor activity was increased in the lungs of mice challenged with IL-1F9 and in a macrophage cell line treated with IL-1F9. These data suggest that IL-1F9 is upregulated during inflammation, and acts as a proinflammatory cytokine in the lungs. | |
| Ramadas RA, et al. Am J Respir Cell Mol Biol. 2011 Feb;44(2):134-45. Epub 2010 Mar 18 | |
IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression |
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| IL-1F6, IL-1F8, and IL-1F9 and the IL-1R6(RP2) receptor antagonist IL-1F5 constitute a novel IL-1 signaling system that is poorly characterized in skin. To further characterize these cytokines in healthy and inflamed skin, we studied their expression in healthy control, uninvolved psoriasis, and psoriasis plaque skin using quantitative RT-PCR and immunohistochemistry. Expression of IL-1F5, -1F6, -1F8, and -1F9 were increased 2 to 3 orders of magnitude in psoriasis plaque versus uninvolved psoriasis skin, which was supported immunohistologically. Moreover, treatment of psoriasis with etanercept led to significantly decreased IL-1F5, -1F6, -1F8, and -1F9 mRNAs, concomitant with clinical improvement. Similarly increased expression of IL-1F5, -1F6, -1F8, and -1F9 was seen in the involved skin of two mouse models of psoriasis. Suggestive of their importance in inflamed epithelia, IL-1α and TNF-α induced IL-1F5, -1F6, -1F8, and -1F9 transcript expression by normal human keratinocytes. Microarray analysis revealed that these cytokines induce the expression of antimicrobial peptides and matrix metalloproteinases by reconstituted human epidermis. In particular, IL-1F8 increased mRNA expression of human β-defensin (HBD)-2, HBD-3, and CAMP and protein secretion of HBD-2 and HBD-3. Collectively, our data suggest important roles for these novel cytokines in inflammatory skin diseases and identify these peptides as potential targets for antipsoriatic therapies. | |
| Johnston A, et al. J Immunol. 2011 Feb 15;186(4):2613-22. Epub 2011 Jan 17. | |
| Human IL-1F9 ELISA kit enables to detect circulating IL-1F9 | |||||||||||||||||||||||||||||||||
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Human IL-1F9 ELISA
Code No.: SK00739-01 Size: 96 T Price: $420.00 USD Standard Range:156-5000 pg/ml Dynamic Range:156-5000 pg/ml Sensitivity: 12 pg/ml Sample Type: serum, EDTA plasma Sample requres: 200 ul, 100 ul per well IntraCV: 6-8% InterCV: 10-12% Protocol: PDF |
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Anti Human
IL1F9 IgG Code No.: A00739-01-100 Size: 100 ug Price: $260.00 USD Host: Rabbit Antigen: ECD of human IL-1F9 Rec. Ab Type: Polyclonal IgG Purification: Protein A Applications: E, IHC Working Dilution: IHC 1: 200 (5 ug/ml) Data Sheet: PDF |
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Human
IL-1F9 Recombinant Code No.: 00739-01-100 Size: 100 ug Price: $360.00 USD Protein ID:Q9NZH8 Gene ID: 56300 MW: 27 KD Tag: His Tag on N-Terminus Expressed: E. Coli Purity: 90% Data Sheet: PDF |
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| Name | Code No. |
Size |
Price ($) |
| Human IL-1F9/IL-36G ELISA Kit | SK00739-01 | 96 T | 420.00 |
| Human IL-1F9/IL-36G, recombinant | 10 ug |
178.00 |
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| Human IL-1F9/IL-36G, recombinant | 50 ug |
280.00 |
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| Human IL-1F9/IL-36G, recombinant | 100 ug |
360.00 |
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| Human IL-1F9/IL-36G, recombinant | 1 mg |
3200.00 |
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| Human IL-1F9/IL-36G Biotinylated | 50 ug |
420.00 |
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| Anti Human IL-1F9/IL-36G IgG | 100 ug |
220.00 |
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| Anti Human IL-1F9/IL-36G IgG Biotinylated | 50 ug |
420.00 |
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| Anti Human IL-1F9/IL-36G Monoclonal IgG | 100 ug |
260.00 |
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| Anti Human IL-1F9/IL-36G Monoclonal IgG Biotinylated | 50 ug |
420.00 |
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| Anti Human IL-1F9/IL-36G Monoclonal IgG | 100 ug |
260.00 |
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| Anti Human IL-1F9/IL-36G Monoclonal IgG | 100 ug |
260.00 |
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| Anti Human IL-1F9/IL-36G Monoclonal IgG | 100 ug |
260.00 |
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| Anti Human IL-1F9/IL-36G Monoclonal IgG | 100 ug |
260.00 |
|
| Anti Human IL-1F9/IL-36G Monoclonal IgG | 100 ug |
260.00 |
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| Anti Human IL-1F9/IL-36G Monoclonal IgG | 100 ug |
260.00 |
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| Anti Human IL-1F9/IL-36G Monoclonal IgG | 100 ug |
260.00 |
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| Anti Human IL-1F9/IL-36G Monoclonal IgG | 100 ug |
260.00 |
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