| Soluble Interleukin 22 Binding Protein | |
IL-22BP is a soluble IL-22 receptor, which lacks a trans-membrane and intracellular domain. IL-22BP specifically binds to IL-22 but not other IL-10 family members, and prevents the binding of IL-22 to membrane bound IL-22R1. The binding of IL-22 to IL-22BP is of 20- to 1000-fold higher affinity compared to its binding to the membrane bound IL-22R1. It is also known that IL-22BP expression is down-regulated in the intestine during tissue damage. However the cellular source of IL-22BP is unclear. Moreover, the mechanism regulating IL-22BP expression and the significance of endogenous IL-22BP in vivo are unknown. Huber S et al. Nature. 2012 Nov 8;491(7423):259-63 |
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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine |
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| Chronic mucosal inflammation and tissue damage predisposes patients to the development of colorectal cancer. This association could be explained by the hypothesis that the same factors and pathways important for wound healing also promote tumorigenesis. A sensor of tissue damage should induce these factors to promote tissue repair and regulate their action to prevent development of cancer. Interleukin 22 (IL-22), a cytokine of the IL-10 superfamily, has an important role in colonic epithelial cell repair, and its levels are increased in the blood and intestine of inflammatory bowel disease patients. This cytokine can be neutralized by the soluble IL-22 receptor, known as the IL-22 binding protein (IL-22BP, also known as IL22RA2); however, the significance of endogenous IL-22BP in vivo and the pathways that regulate this receptor are unknown. Here we describe that IL-22BPhas a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon. IL-22BP is highly expressed by dendritic cells in the colon in steady-state conditions. Sensing of intestinal tissue damage via the NLRP3 or NLRP6 inflammasomes led to an IL-18-dependent downregulation of IL-22BP, thereby increasing the ratio of IL-22/IL-22BP. IL-22, which is induced during intestinal tissue damage, exerted protective properties during the peak of damage, but promoted tumour development if uncontrolled during the recovery phase. Thus, the IL-22-IL-22BP axis critically regulates intestinal tissue repair and tumorigenesis in the colon. | |
| Huber S et al. Nature. 2012 Nov 8;491(7423):259-63 | |
| Human Soluble IL-22 Binding Protein Recombinant Code No.: 00527-01-100 Size: 100 ug Price: $360.00 USD Protein ID:NP851826 Gene ID:NM_181309 MW:26 KD Tag: His Tag on N-Terminus Expressed: E. Coli Purity: 95% Data Sheet: PDF |
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Human
Interleukin 22 ELISA Code No.: SK0279-01 Size: 96 T Price: $360.00 USD Standard Range:3.125-500 pg/ml Sensitivity: 1 pg/ml Sample Type:serum or EDTA plasma Sample Volume: 100 uL per well IntraCV: 6-8% InterCV: 10-12% Data Sheet: PDF |
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| Name | Code No. |
Size |
Price ($) |
| Anti Interleukin-22 Binding Protein (Soluble) (Human) IgG | IgG100 ug |
260.00 |
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| Anti Interleukin-22 Binding Protein (Soluble) (Human) IgG Biotinylated | IgG50 ug |
320.00 |
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| Interleukin-22 Binding Protein (Soluble) (Human) Rec. | 10 ug |
80.00 |
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| Interleukin-22 Binding Protein (Soluble) (Human) Rec. | 50 ug |
200.00 |
|
| Interleukin-22 Binding Protein (Soluble) (Human) Rec. | 100 ug |
380.00 |
|
| Interleukin-22 Binding Protein (Soluble) (Human) Rec. Biotinylated | 50 ug |
390.00 |
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| Interleukin-22 Binding Protein (Soluble) (Human) Rec. Cy5 conjugated | 00527-01-50C5 |
50 ug |
420.00 |
| Interleukin-22 Binding Protein (Soluble) (Human) Rec. FITC conjugated | 00527-01-50F |
50 ug |
380.00 |
| Interleukin-22 (Human) Rec. | 00279-01-5 |
5 ug |
180.00 |
| Inteleukin 22 (IL-22) (Human) ELISA | 96 T |
360.00 |