| IL-33 ELISA Kit, Antibody & Proteins | |
| A Biomarker for Cardiovascular Diseases | |
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| IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline | |
| Dysfunction of the innate immune system is involved in the pathogenesis of Alzheimer’s disease (AD); however, the pathophysiological mechanisms underlying these dysfunctions are unclear. Here we report that stimulation of IL-33/ST2 signaling rescues memory deficits and reduces the accumulation of ß-amyloid in APP/PS1 mice that exhibit select pathologies associated with AD. Although impaired IL-33/ST2 signaling is associated with early progression of AD, IL-33 injection rescues contextual memory deficits and reduces the accumulation of ß-amyloid in APP/PS1 mice. IL-33 skews the microglia toward an alternative activation state with enhanced Aß phagocytic capacity and elevated antiinflammatory gene expression, which results in a decreased proinflammatory response in the brain. Thus, this study suggests that IL-33 can be developed as a new therapeutic intervention for AD. | |
| Amy K. Y. Fu, et al. PNAS 2016, April 18, vol. 113 no. 19, E2705–E2713, doi: 10.1073/pnas.1604032113 | |
| New Anti Human IL-33 monoclonal and polyclonal antibodies are raised and selected with high purity recombinant human IL-33 protein. The bulk size antibodies are available. | |
| Interleukin-33, a Novel Member of the IL-1/IL-18 Cytokine Family, in Cardiology and Cardiac Surgery | |
| Interleukin-33 is a newly recognized cytokine of the IL-1 family. Unlike its other members IL-1α, IL-1β and IL-18, interleukin-33 induces predominantly Th2-skewed immune responses. In this context, the effects of IL-33 are mostly anti-inflammatory. However, depending on the actual cytokine and cellular milieu, IL-33 can promote both Th1 and Th2 immune reactions. Most importantly for cardiology and cardiac surgery, IL-33 has emerged to represent the as yet unknown ligand of the orphan receptor ST2. Before the advent of IL-33, the ST2 receptor, currently recognized as the soluble one of its two isoforms, was considered to be an unfavorable prognostic marker in myocardial infarction, congestive heart failure and trauma/sepsis shock patients. Now we know that IL-33, when bound to the cellular membrane-anchored ST2L isoform of the receptor, can have certain beneficial effects on the aforementioned conditions. Various forms of IL-33 interaction with the respective isoforms of its cognate receptor are discussed here. The focus is on physiological and prognostic values in cardiac patients. | |
| Kunes P, et al. Thorac Cardiovasc Surg. 2010 Dec;58(8):443-9. Epub 2010 Nov 26. | |
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Human IL-33 ELISA Kit Code No.: SK00277-06 Size: 96T Price: $420.00 USD Standard Range:78-5000 pg/mL Sensitivity:15 pg/mL Sample Type: serum,cell cultures, Sample volume: 100 uL Dilution factor: N/A IntraCV: 4-6% InterCV: 8-12% Protocol:PDF |
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Human IL-33 ELISA Kit Code No.: SK00277-09 Size: 96T Price: $420.00 USD Standard Range:78-5000 pg/mL Sensitivity:15 pg/mL Sample Type: serum,cell cultures, Sample volume: 100 uL Dilution factor: N/A IntraCV: 4-6% InterCV: 8-12% Protocol:PDF |
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Mouse IL-33 ELISA Kit Code No.: SK00277-03 Size: 96T Price: $390.00 USD Standard Range:25-1500 pg/mL Sensitivity:10 pg/mL Sample Type: serum,cell cultures, Sample volume: 100 uL Dilution factor: N/A IntraCV: 4-6% InterCV: 8-12% Protocol:PDF |
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Human IL-33
Recombinant Code No.: 00277-01-100 Size: 100 ug Price: $460.00 USD Protein ID:O95760 Gene ID: 90865 MW: 18 KD Tag: His Tag on N-Terminus Expressed: E. Coli Purity: 95% Data Sheet: PDF |
| Anti IL-33
(Human) IgG Code No.: A00277-01-100 Size: 100 ug Price: $260.00 USD Target Protein ID:O95760 Target Gene ID: 90865 Host: Rabbit Immunogen: Human IL-33 Rec. Antibody Type: Polyclonal IgG Purification: Protein A Applications: E, IHC (2-4 ug/ml) Data Sheet: PDF |
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| Anti IL-33
(Human) Monoclonal Antibody Code No.: A00277-02-100 Size: 100 ug Price: $360.00 USD Clone: 2E2E2G6 Target Protein ID:O95760 Target Gene ID: 90865 Host: Rabbit Immunogen: Human IL-33 Rec. Antibody Type: Monoclonal Purification: Protein G Applications: ELISA (capture) Data Sheet: PDF |
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| Name | Code No. |
Size |
Price ($) |
| Human IL-33 ELISA Kit (Serum) | 96 T |
420.00 |
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| Human IL-33 ELISA Kit (Serum) | SK00277-06B | 192 T | 800.00 |
| Human IL-33 ELISA Kit (Serum) | SK00277-06F | 480 T | 1800.00 |
| Human IL-33 ELISA Kit (Serum) | SK00277-06T | 960 T | 3000.00 |
| Human IL-33 ELISA Kit (Serum) | 96 T |
420.00 |
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| Human IL-33 ELISA Kit (Serum) | SK00277-09B | 192 T | 800.00 |
| Human IL-33 ELISA Kit (Serum) | SK00277-09F | 480 T | 1800.00 |
| Human IL-33 ELISA Kit (Serum) | SK00277-09T | 960 T | 3000.00 |
| Mouse IL-33 ELISA Kit | SK00277-03 | 96 T | 390.00 |
| Human Soluble IL-1R4/ST2 ELISA Kit | 96 T |
390.00 |
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| Mouse Soluble IL-1R4/ST2 ELISA Kit | 96 T |
390.00 |
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| IL-33 (Human) recombinant | 00277-01-100 | 100 ug | 460.00 |
| IL-33 (Human) Recombinant | 00277-01-50 | 50 ug | 310.00 |
| Anti IL-33 (Human) IgG | A00277-01-100 | 100 ug | 260.00 |
| Anti IL-33 (Human) IgG Biotinylated | A00277-01-50B | 50 ug | 300.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-02-100 | 100 ug | 320.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-02-1000 | 1 mg | Inquire |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-03-100 | 100 ug | 320.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-03-1000 | 1 mg | Inquire |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-04-100 | 100 ug | 260.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-04-1000 | 1 mg | Inquire |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-10-100 | 100 ug | 220.00 | Anti IL-33 (Human) Monoclonal Antibody | A00277-10-1000 | 1000 ug | Inquire |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-10-50B | 50 ug | 320.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-10-500B | 500 ug | Inquire |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-11-100 | 100 ug | 220.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-11-1000 | 1 mg | Inquire |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-11-50B | 50 ug | 320.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-12-100 | 100 ug | 220.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-12-1000 | 1 mg | Inquire |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-12-50B | 50 ug | 320.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-14-100 | 100 ug | 220.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-14-1000 | 1 mg | Inquire |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-14-50B | 50 ug | 320.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-15-100 | 100 ug | 220.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-15-1000 | 1 mg | Inquire |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-15-50B | 50 ug | 320.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-16-100 | 100 ug | 220.00 |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-16-1000 | 1 mg | Inquire |
| Anti IL-33 (Human) Monoclonal Antibody | A00277-16-50B | 50 ug | 320.00 |
| IL-33 (Mouse) Rec. | 00277-03-05 | 5 ug | 149.00 |