| V-set and transmembrane domain containing 2 like (VSTM2L)is a antagonist of humanin | |
Alternative name:
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VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin |
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Humanin (HN) is a
24-residue peptide displaying a protective activity
in vitro
against a range of cytotoxic and neurotoxic insults, as well as
mediating in
vivo amelioration of Alzheimer disease (AD)-related memory
impairment in experimental models. Published evidence suggests
that the mechanisms through which HN exerts its cyto- and
neuroprotective activity may include its secretion and binding to
membrane-associated receptors. Here, we describe the
identification of a new modulator of HN neuroprotective activity,
V-set and transmembrane domain containing 2 like (VSTM2L),
previously known as C20orf102. VSTM2L interacts with HN in both
yeast and mammalian cells, is secreted in cultured cells, is
present in serum, and is selectively expressed in the central
nervous system. VSTM2L colocalizes with HN in distinct brain areas
as well as in primary cultured neurons, where it plays a role in
the modulation of neuronal viability. When tested in HN
neuroprotection bioassays, VSTM2L acts as a strong antagonist of
HN neuroprotective activity. In summary, VSTM2L is the first
example of a secreted antagonist of HN and may play a role in the
modulation of HN biological functions—Rossini, L., Hashimoto, Y.,
Suzuki, H., Kurita, M., Gianfriddo, M., Scali, C., Roncarati, R.,
Franceschini, D., Pollio, G., Trabalzini, L., Terstappen, G. C.,
Matsuoka, M., Caricasole, A. VSTM2L is a novel secreted antagonist
of the neuroprotective peptide Humanin. |
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| Lara Rossini, et al. Published online before print March 10, 2011, doi: 10.1096/fj.10-163535 fj.10-163535 | |
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Anti Human
VSTM2L IgG Code No.: A00820-01-100 Size: 100 ug Price: $260.00 USD Host: Rabbit Antigen: human VSTM2L Rec. Ab Type: IgG1 Purification: Protein A Applications: E, IHC Data Sheet: PDF |
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Anti Human
VSTM2L IgG Code No.: A00820-03-100 Size: 100 ug Price: $260.00 USD Host: Rabbit Antigen: human VSTM2L (25-166) Rec. Ab Type: IgG Purification: Protein A Applications: E, IHC Data Sheet: PDF |
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Human
VSTM2L Recombinant Code No.: 00820-01-100 Size: 100 ug Price: $460.00 USD Protein ID:Q96N03 Gene ID: 128434 MW: 23.83 KD Tag: His Tag on N-Terminus Expressed: E. Coli Purity: 95% Data Sheet: PDF |
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Human
VSTM2L(25-132) Recombinant Code No.: 00820-02-100 Size: 100 ug Price: $360.00 USD Protein ID:Q96N03 Gene ID: 128434 MW: 15.93 KD Tag: His Tag on N-Terminus Expressed: E. Coli Purity: 95% Data Sheet: PDF |
 |
Human
VSTM2L(25-166) Recombinant Code No.: 00820-03-100 Size: 100 ug Price: $360.00 USD Protein ID:Q96N03 Gene ID: 128434 MW: 19.83 KD Tag: His Tag on N-Terminus Expressed: E. Coli Purity: 95% Data Sheet: PDF |
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| Name/td> | Code No. |
Size |
Price ($) |
| VSTM2L (Human), recombinant | 100 ug |
460.00 |
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| VSTM2L (Human), Cy3 conjugated | 00820-01-50C3 |
50 ug |
590.00 |
| VSTM2L (Human), FAM conjugated | 00820-01-50FAM |
50 ug |
560.00 |
| VSTM2L (Human), biotinylated | 00820-01-50B |
50 ug |
540.00 |
| Anti VSTM2L (Human) IgG | 100 ug |
260.00 |
|
| Anti VSTM2L (Human)IgG | A00820-06-100 |
100 ug |
360.00 |
| VSTM2L (25-132) (Human) Rec. | 100 ug |
360.00 |
|
| VSTM2L (25-166) (Human) Rec. | 00820-03-100 | 100 ug | 360.00 |
| Anti VSTM2L (25-166) (Human) IgG | A00820-03-100 | 100 ug | 260.00 |
| Anti VSTM2L (25-166) (Human) IgG Biotinylated | A00820-03-50B | 100 ug | 260.00 |