Soluble Receptor for Advanced Glycosylation End Products (sRAGE) ELISA, Antibody & Recombinant sRGAE is a novel biomarker for cardiovascular diseases Rat Soluble RAGE recombinant (catalog No.: 00112-03-100)had been used by Dr. Guo on her research paper: Caixia Guo, et al. A Soluble Receptor for Advanced Glycation End-Products Inhibits Hypoxia/Reoxygenation-Induced Apoptosis in Rat Cardiomyocytes via the Mitochondrial Pathway.Int J Mol Sci. 2012;13(9):11923-40. Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats Objective: Advanced glycation end-products (AGEs) exert inflammatory and oxidative stress insults to produce diabetic nephropathy mainly through the receptor for AGEs (RAGE). This study aimed to assess the effect of atorvastatin on diabetic nephropathy via soluble RAGE (sRAGE) and RAGE expressions in the rat kidney. Methods: Thirty-two male Sprague-Dawley rats were divided into four groups based on the presence or absence of streptozotocin-induced diabetes with or without atorvastatin treatment (10 mg/kg for 24 weeks). Serum sRAGE and glycated albumin (GA) levels were measured with enzyme-linked immunosorbent assay (ELISA) and improved bromocresol purple methods. Renal AGEs, RAGE, endogenous secretory RAGE (esRAGE), and sRAGE were determined with reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting. Results: Mesangial expansion and microalbuminuria were aggravated in diabetic rats, and improved with atorvastatin treatment. Serum sRAGE levels were lower in diabetic than in normal rats. After atorvastatin treatment, serum and renal sRAGE levels were up-regulated, while renal RAGE expression was decreased in diabetic rats, associated with a reduction in accumulation of AGEs, though renal esRAGE mRNA expression was not significantly increased. Conclusions: Atorvastatin exerted a beneficial effect on diabetic nephropathy with reduced AGE accumulation, down-regulating RAGE expression and up-regulating sRAGE in the kidney. Lu L., et al. J Zhejiang Univ Sci B. 2011 August; 12(8): 652–659.
		sRAGE (Human) Recombinant
		Code No.:00112-01-100 Size: 100ug Portein ID: Q15109 Gene ID: 177 MW : 39 KD Tag : 6x His Tag on N-Terminus Expressed : E. Coli More info: Data Sheet
		sRAGE (Rat) Recombinant
		Code No.:00112-03-100 Size: 100ug Portein ID: Q63495 Gene ID: Rn.9829 MW : 33.9 KD Tag : 6x His Tag on N-Terminus Expressed : E. Coli More info: Data Sheet
		Anti sRAGE (Human) IgG
		Code No.: A00112-02-100 Size: 100 ug Ab Type: Polyclonal IgG Purification: Protein A Host: Rabbit Antigen: sRAGE (Human) rec. Positive tissues: paraffin-embedded human kidney tissues Working Conc.: 2 ug/ml (Overnight incubation) Protocol: ABC More Info: PDF
		Haman sRAGE ELISA Kit Code No.: SK00112-02 Size: 96T Sensitivity: 20 pg/ml Standard rage: 78-5000 pg/ml Sample type: Serum, Plasma Sample Volume: 100 uL Intra CV: 6-8% Inter CV: 10-12% More Info: Protocol
		Rat/Mouse sRAGE ELISA Kit
		Code No.:SK00112-03 Size: 96T Standard Range: 0.026-400 ng/ml Linear range: 130-80000 pg/ml Sensitivity: 50 pg/ml Specificity: Mouse, Rat Sample type: serum or plasma Intra CV: 6-8% Inter CV: 10-12% More Info: Protocol
		Anti sRAGE (Rat) IgG
		Code No.: A00112-03-100 Size: 100 ug Ab Type: Polyclonal IgG Purification: Protein A Host: Rabbit Antigen: sRAGE (Rat), rec Positive tissues: paraffin-embedded rat and mouse kidney tissues Working Conc.: 2 ug/ml (Overnight incubation) Protocol: ABC More Info: PDF
		Anti esRAGE (Human) IgG
		Code No.: A00112-09-100 Size: 100 ug Ab Type: Polyclonal IgG Purification: Protein A Host: Rabbit Antigen: human esRAGE C-Terminal Rec Positive tissues: paraffin-embedded human and rat visceral adipose tissues Working Conc.: 2 ug/ml (Overnight incubation) Protocol: ABC More Info: PDF
		Anti esRAGE (Human) IgG
		Code No.: A00112-09-100 Size: 100 ug Ab Type: Polyclonal IgG Purification: Protein A Host: Rabbit Antigen: human esRAGE C-Terminal Rec Positive tissues: paraffin-embedded human and rat visceral adipose tissues Working Conc.: 2 ug/ml (Overnight incubation) Protocol: ABC More Info: PDF

Rabbit Anti esRAGE (Human) IgG (A00122-09-100) is available in stock that enables to detect esRAGE in serum. This antiobdy does not indicated crossreactivity with recombinat human sRAGE on ELISA.

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