line decor
  HOME  ::  
line decor
chemokine (C-C motif)Ligand 18 (CCL18/PARC) ELISA Kit

A biomarker for cancer, acute coronary syndromes and Interstitial lung disease

Alternative name:

  • Pulmonary and activation-regulated chemokine
  • chemokine (C-C motif) ligand 18
CCL18/PARc is a chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. CCL18 was expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. CCL18 was not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. CCL18 was expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. The serum levels of CCL18 were increased in patients with non-small-cell-lung cancer, acute coronary syndromes and systemic sclerosis.

Chemokines CCL3/MIP1α, CCL5/RANTES and CCL18/PARC are Independent Risk Predictors of Short-Term Mortality in Patients with Acute Coronary Syndromes

Cytokines play an important role in ischemic injury and repair. However, little is known about their prognostic value in cardiovascular disease. The aim of this study was to investigate the prognostic importance of chemokines CCL3/MIP-1α, CCL5/RANTES and CCL18/PARC for the risk of future cardiovascular events in patients with acute coronary syndromes (ACS). Baseline levels of CCL3/MIP-1α, CCL5/RANTES and CCL18/PARC were determined in ACS patients from the Bad Nauheim ACS II registry (n = 609). During the following 200 days, patients were monitored for the occurrence of fatal and non-fatal cardiovascular events. Patients with CCL3/MIP1α, CCL5/RANTES and CCL18/PARC concentrations in the highest tertile were associated with an increased risk of a fatal event during follow-up (HR: 2.19, 95%CI: 1.04-4.61 for CCL3/MIP1α, HR: 3.45, 95%CI: 1.54-7.72 for CCL5/RANTES and HR: 3.14, 95%CI: 1.33-7.46 for CCL18/PARC). This risk was highest for patients with all three biomarkers concentrations in the upper tertile (HR: 2.52, 95%CI: 1.11-5.65). Together with known risk predictors of cardiovascular events, CCL3/MIP-1α, CCL5/RANTES andCCL18/PARC combined improved the c-statistics from 0.74 to 0.81 (p = 0.007). In conclusion, CCL3/MIP-1α, CCL5/RANTES and CCL18/PARC are independently associated with the risk of short-term mortality in ACS patients. Combining all three biomarkers further increased their prognostic value.
de Jager SC, et alPLoS One. 2012;7(9):e45804. doi: 10.1371/journal.pone.0045804. Epub 2012 Sep 21.
Code No.:SK 00466-01
Size: 96 T
Price: $360.00 USD
Standard range: 15.6-1000 pg/ml
Sensitivity: 5-7 pg/ml
Sample type: serum, plasma, cell cultures
Dilution Factor:200 for serum or plasma samples
Intra-CV: 6-8%
Inter-CV: 8-10%
Data Sheet: PDF


Code No.
Price ($)
CCL18/PARc (Human) ELISA Kit SK00466-01 96 T 360.00