| FGF-21 (Human) ELISA KIT | |
FGF21 (Mouse/Rat) ELISA Kit |
|
Mouse FGF-21 ELISA Kit SK00145-08 had been used by Dr. Liu on following research papers, Gao M1 and Liu D. Cold Exposure Improves the Anti-diabetic Effect of T0901317 in Streptozotocin-Induced Diabetic Mice. AAPS J. 2015 May;17(3):700-10. Gao M1 and Liu D. Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet. J Control Release. 2014 Jul 10;185:1-11 |
|
Mouse FGF-21 ELISA Kit SK00145-08 had been used by Dr. Leng Y on following research paper |
|
FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers |
|
| Fibroblast growth factor-21 (FGF-21) is a new member of the FGF super-family and an important endogenous regulator of glucose and lipid metabolism. It has been proposed as a therapeutic target for diabetes and obesity. Its function in the central nervous system (CNS) remains unknown. Previous studies from our laboratory demonstrated that aging primary neurons are more vulnerable to glutamate-induced excitotoxicity, and that co-treatment with the mood stabilizers lithium and valproic acid (VPA) induces synergistic neuroprotective effects. This study sought to identify molecule(s) involved in these synergistic effects. We found that FGF-21 mRNA was selectively and markedly elevated by co-treatment with lithium and VPA in primary rat brain neurons. FGF-21 protein levels were also robustly increased in neuronal lysates and culture medium following lithium-VPA co-treatment. Combining glycogen synthase kinase-3 (GSK-3) inhibitors with VPA or histone deacetylase (HDAC) inhibitors with lithium synergistically increased FGF-21 mRNA levels, supporting that synergistic effects of lithium and VPA are mediated via GSK-3 and HDAC inhibition, respectively. Exogenous FGF-21 protein completely protected aging neurons from glutamate challenge. This neuroprotection was associated with enhanced Akt-1 activation and GSK-3 inhibition. Lithium-VPA co-treatment markedly prolonged lithium-induced Akt-1 activation and augmented GSK-3 inhibition. Akt-1 knockdown markedly decreased FGF-21 mRNA levels and reduced the neuroprotection induced by FGF-21 or lithium-VPA co-treatment. In addition, FGF-21 knockdown reduced lithium-VPA co-treatment-induced Akt-1 activation and neuroprotection against excitotoxicity. Together, our novel results suggest that FGF-21 is a key mediator of the effects of these mood stabilizers and a potential new therapeutic target for CNS disorders. | |
| Leng Y., et al. Mol Psychiatry. 2015 Feb;20(2):215-23. | |
 |
|
 |
|
 |
|
 |
|
|
Human FGF21 ELISA Code No.: SK00145-01 Size: 96 T Price: $420.00 USD Standard Range:15.6-2000 pg/ml Sample Type:serum, EDTA plasma Sample Volume: 100 uL Dilution Factor: Intra CV: 4% Inter CV: 8% Protocol: PDF |
 |
Mouse FGF21 ELISA Code No.: SK00145-08 Size: 96 T Price: $420.00 USD Standard Range:15.6- 1000 pg/ml caliberation: Mouse FGF-32 recombinant Sample Type: Serum, EDTA plasma Sample Volume: 100 uL Dilution Factor: Intra CV: 4% Inter CV: 8% Protocol: PDF Rat serum or EDTA plasma samples cross-react with this mouse FGF-21 ELISA Kit |
 |
Mouse FGF21 ELISA Code No.: SK00145-23 Size: 96 T Price: $460.00 USD Standard Range: 15.6-1000 pg/ml Caliberation: Mouse FGF-32 recombinant Specificity: Mouse, Rat Sample Type: Serum, EDTA plasma Sample Volume: 100 uL Dilution Factor: Intra CV: 4-6% Inter CV: 8-12% Protocol: PDF |
 |
Human FGF21 Recombinant |
 |
Human FGF19-21 Recombinant |
 |
Anti Human FGF21 IgG Code No.:00145-02-100 Size: 100 ug Price: $200.00 USD Host: Rabbit Immunohen: Human FGF21, Rec Antibody Type:Polyclonal IgG Purification:Protein A affinity Carry: free Formulation: PBS lyophilized Storage: -20 oC ~ -70oC Data Sheet: PDF |
 |
Anti Mouse FGF21 IgG Code No.:00145-03-100 Size: 100 ug Price: $200.00 USD Host: Rabbit Immunohen:Mouse FGF21, Rec Antibody Type:Polyclonal IgG Purification:Protein A affinity Carry: free Formulation: PBS lyophilized Storage: -20 oC ~ -70oC Data Sheet: PDF |
 |
Anti Human FGF21 IgG Code No.:00145-02-100 Size: 100 ug Price: $200.00 USD Host: Rabbit Immunohen: Human FGF21, Rec Antibody Type:Polyclonal IgG Purification:Protein A affinity Carry: free Formulation: PBS lyophilized Storage: -20 oC ~ -70oC Data Sheet: PDF |
 |
Anti Mouse FGF21 IgG Code No.:00145-03-100 Size: 100 ug Price: $200.00 USD Host: Rabbit Immunohen:Mouse FGF21, Rec Antibody Type:Polyclonal IgG Purification:Protein A affinity Carry: free Formulation: PBS lyophilized Storage: -20 oC ~ -70oC Data Sheet: PDF |
 ELISA Kit SK00145-01.jpg)
| Name | Code No. |
Size |
Price ($) |
| Human FGF21 ELISA Kit | 96 T |
420.00 |
|
| Human FGF21 ELISA Kit | SK00145-02 |
96 T |
420.00 |
| Mouse/Rat FGF21 ELISA Kit | 96 T |
420.00 |
|
| Mouse FGF21 ELISA Kit | 96 T |
420.00 |
|
| Mouse FGF21 ELISA Kit | 96 T |
460.00 |
|
| Human FGF21 ELISA Set ( 10 x 96 T) (components) | SK00145-10 |
Set |
620.00 |
| Mouse FGF21 ELISA Set (10 x 96 T) (components) | SK00145-20 |
Set |
620.00 |
| Human FGF21 His Tag Recombinant | 00145-02-10 |
10 ug |
65.00 |
| Human FGF21 His Tag Recombinant | 00145-02-20 |
20 ug |
120.00 |
| Human FGF21 His Tag Recombinant | 00145-02-50 |
50 ug |
195.00 |
| Human FGF21 His Tag Recombinant | 100 ug |
300.00 |
|
| Human FGF21 His Tag Recombinant | 00145-02-1000 |
1 mg |
1500.00 |
| Human FGF19-21 Chimera | 100 ug |
580.00 |
|
| Mouse FGF-21 Recombinant | 100 ug |
300.00 |
|
| Mouse FGF-21 His Tag Recombinant | 00145-03-10 |
10 ug |
65.00 |
| Mouse FGF-21 His Tag Recombinant | 00145-03-20 |
20 ug |
120.00 |
| Mouse FGF-21 His Tag Recombinant | 00145-03-50 |
50 ug |
195.00 |
| Mouse FGF-21 Recombinant | 00145-03-500 |
500 ug |
1200.00 |
| Mouse FGF-21 His Tag Recombinant | 00145-03-1000 |
1 mg |
1500.00 |
| anti FGF-21 (Human) Monoclonal Antibody | 100 ug |
395.00 |
|
| anti FGF-21 (Human) Monoclonal Antibody | A00145-01-25 |
25 ug |
125.00 |
| Anti FGF-21 (Human) IgG | 100 ug |
200.00 |
|
| Anti FGF-21 (Human) IgG | A00145-02-25 |
25 ug |
80.00 |
| Anti FGF-21 (Mouse) IgG | 100 ug |
220.00 |
|
| anti FGF-21 (Human) Monoclonal Antibody | 100 ug |
395.00 |
|
| anti FGF-21 (Human) Monoclonal Antibody | 100 ug |
260.00 |
|
| anti FGF-21 (Human) Monoclonal Antibody | 100 ug |
260.00 |
|
| anti FGF-21 (Human) Monoclonal Antibody | 100 ug |
260.00 |
|
| anti FGF-21 (Human) Monoclonal Antibody | 100 ug |
260.00 |
|
| anti FGF-21 (Human) Monoclonal Antibody | 100 ug |
260.00 |
|
| anti FGF-21 (Human) Monoclonal Antibody | 100 ug |
260.00 |
|
| anti FGF-21 (Human) Monoclonal Antibody | 100 ug |
260.00 |
|
| anti FGF-21 (Human) Monoclonal Antibody | 100 ug |
260.00 |