CTRP4 ELISA, Protein Antibody
(Complement C1q Tumor necrosis factor-Related Protein 4); CTRP4 has two globular form. |
Alternative name:
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C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight |
CTRP4 is a unique member of the C1q family, possessing two tandem globular C1q domains; its physiological function is poorly defined. Here, we show that CTRP4 is an evolutionarily conserved ~34 kDa secretory protein expressed in the brain. In human, mouse, and zebrafish brain, CTRP4expression begins early in development and is widespread in the central nervous system. Neurons, but not astrocytes, express and secrete CTRP4, and secreted proteins form higher-order oligomeric complexes. CTRP4 is also produced by peripheral tissues and circulates in blood; its serum levels are increased in leptin-deficient obese (ob/ob) mice. Functional studies suggest that CTRP4 acts centrally to modulate energy metabolism. Re-feeding following an overnight fast induced the expression of CTRP4 in the hypothalamus. Central administration of recombinant protein suppressed food intake and altered whole-body energy balance in both chow-fed and high-fat diet-fed mice. Suppression of food intake by CTRP4 is correlated with decreased expression of orexigenic neuropeptide (Npy and Agrp) genes in the hypothalamus. These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance. |
Byerly MS et al. J Biol Chem. 2013 Dec 23. [Epub ahead of print] |
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Code No.: SK00090-06
Size: 96 T
Price: $490.00 USD
Standard range:1.56-100 ng/ml
Sensitivity: 300 pg/ml
Sample Type: serum, plasma
sample require: 100 uL per well
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet: PDF |
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Code No.: SK00090-07
Size: 96 T
Price: $460.00 USD
Standard range:1.56-100 ng/ml
Sensitivity: 390 pg/ml
Sample Type: serum, plasma
sample require: 100 uL per well
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet: PDF |
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Code No.: A00090-07-100
Size: 100 ug
Price: $360.00 USD
Clone: 1F1D4F6
Antibody Type: IgG
Purification: Protein G
Antigen:CTRP4 (Human) (25-162)
Applications: WB (1-2 ug/ml), ELISA
Data Sheet: PDF
Validated Antibody by WB and ELISA |
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Code No.: A00090-02-100
Size: 100 ug
Price: $260.00 USD
Host: Rabbit
Antigen: human CTRP4 (25-162) Rec.
Ab Type: Polyclonal IgG
Purification: Protein A
Applications: E, IHC (2 ug/ml)
Data Sheet: PDF
Validated Antibody by IHC and ELISA |
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Code No.: A00090-09-100
Size: 50 ug
Price: $360.00 USD
Clone: 2B1C6H11
Antibody Type: IgG
Purification: Protein G
Antigen:CTRP4 (Human) globular form
Applications: WB (1-2 ug/ml), ELISA
Data Sheet: PDF
Validated Antibody by WB and ELISA |
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Code No.: A00090-04-100
Size: 100 ug
Price: $360.00 USD
Clone: F11C12
Antibody Type: IgG
Purification: Protein G
Antigen:CTRP4 (Human) (172-317)
Applications: WB (1-2 ug/ml), ELISA
Data Sheet: PDF
Validated Antibody by WB and ELISA |
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Anti Human CTRP4
Monoclonal Antibody
Code No.: A00090-05-100
Size: 100 ug
Price: $360.00 USD
Clone: C1C12
Antibody Type: IgG
Purification: Protein G
Antigen:CTRP4 (Human) (172-317)
Applications: WB (1-2 ug/ml), ELISA
Data Sheet: PDF
Validated Antibody by WB and ELISA |
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Code No.: 00090-01-100
Size: 100 ug
Price: $360.00 USD
Protein ID:Q9BXJ3
Gene ID: 114900
MW:19.9 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 90%
Data Sheet: PDF |
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Code No.: 00090-02-100
Size: 100 ug
Price: $360.00 USD
Protein ID:Q9BXJ3
Gene ID: 114900
MW:18.7 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 90%
Data Sheet: PDF
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Mouse CTRP4 Full Length (17-326) Recombinant
Code No.: 00090-21-100
Size: 100 ug
Price: $490.00 USD
Sequence: 17Leu-326Leu
Protein ID:NP_080437.2Q8R066-1
Gene ID: NM_026161.3
MW: 37.1 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF
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Code No.: 00090-22-100
Size: 100 ug
Price: $390.00 USD
Sequence: 24Ser-161Ala
Protein ID:NP_080437.2Q8R066-1
Gene ID: NM_026161.3
MW:18.73 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF |
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